NCT03294408: MOSART

Multimodal Imaging of Subchondral Bone in Knee Osteoarthritis : Predictive Model

Completed NA Last updated 28 November 2025

What this trial tests

NA trial testing multimodal imaging in Knee Osteoarthritis in 167 participants. Completed in 19 June 2023.

Timeline

29 November 2016

Primary endpoint
19 June 2023

19 June 2023

Quick facts

Lead sponsor	Centre Hospitalier Régional d'Orléans
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	167
Start date	29 November 2016
Primary completion	19 June 2023
Estimated completion	19 June 2023
Sites	2 locations across France

Drugs / interventions tested

• multimodal imaging

Conditions studied

• Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
• Joint Disease — all drugs for Joint Disease →
• Arthritis — all drugs for Arthritis →
• Musculoskeletal Disease — all drugs for Musculoskeletal Disease →

Sponsor

Centre Hospitalier Régional d'Orléans

Who can join

Adults 45 to 80, any sex, with Knee Osteoarthritis or Joint Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Predictive factors of osteoarthritis progression are not yet well understood. However, a growing role attaches importance to the subchondral bone. The aim of the present project is to determine predictive factors of progression of osteoarthritis at the knee by a multimodal characterization of subchondral bone by Medical Resonnance Imaging, direct high resolution digitization radiographs and bone texture analysis. At the end of the project, an innovative imaging device, combining semi-automatic softwares for texture analysis, control detection and image registration would be supplied. This will enable on the one hand a more accurate and reproducible way to measure the joint space width of the affected compartment and on the other hand, an assistance to better detect patients at risk of progression of their knee osteoarthritis. Identifying These "progressors" patients might permit their selection in clinical trials at baseline adapted to their severe disease, using for example biologic treatments targeting knee osteoarthritis. The main objective of this study is to analyze the predictive capacities of bone texture parameters measured on the high-resolution radiography of the knee on the structural evolution of the knee osteoarthritis at 3 years.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.