NCT03288181

Effects of Passive Muscle Stretching on Vascular Function and Symptoms of PAD

Completed NA Last updated 19 September 2017

What this trial tests

NA trial testing Muscle Stretch in Peripheral Arterial Disease in 13 participants. Completed in 15 June 2016.

Timeline

5 October 2015

Primary endpoint
30 May 2016

15 June 2016

Quick facts

Lead sponsor	Tallahassee Research Institute, Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	13
Start date	5 October 2015
Primary completion	30 May 2016
Estimated completion	15 June 2016

Drugs / interventions tested

• Muscle Stretch

Conditions studied

• Peripheral Arterial Disease — all drugs for Peripheral Arterial Disease →
• Claudication — all drugs for Claudication →

Sponsor

Tallahassee Research Institute, Inc.

Who can join

Eligibility, any sex, with Peripheral Arterial Disease or Claudication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with peripheral arterial disease often have walking impairment due to insufficient oxygen supply to lower extremity skeletal muscle. In an aging rat model, we have previously shown that daily calf muscle stretching improves endothelium-dependent dilation of soleus muscle arterioles and blood flow during exercise. The effect of muscle stretching on endothelial function and walking distance in patients with peripheral arterial disease is unknown. We performed a prospective, randomized, non-blinded, crossover study in 13 patients with stable symptomatic peripheral artery disease. Patients were randomized to undergo either 4 weeks of passive calf muscle stretching (ankle dorsiflexion splints applied 30 minutes/day, 5 days/week) followed by 4 weeks of no muscle stretching (control group) and vice versa. Endothelium-dependent flow-mediated dilation and endothelium- independent nitroglycerin-induced dilation of the popliteal artery and a 6 minute walk test were evaluated at baseline and after each 4 week treatment interval. Patients crossed over to the other treatment arm after 4 weeks and endothelium-dependent flow-mediated dilation and endothelium- independent nitroglycerin-induced dilation of the popliteal artery and the 6 minute walk test were repeated.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.