NCT03286335 is a NA clinical trial of Proton Radiation in Brain Tumor, sponsored by Massachusetts General Hospital.

Who is sponsoring NCT03286335?

NCT03286335 is sponsored by Massachusetts General Hospital.

What drugs are being tested in NCT03286335?

Interventions in NCT03286335: Proton Radiation.

What condition does NCT03286335 study?

NCT03286335 studies Brain Tumor.

Is NCT03286335 still recruiting?

NCT03286335 is currently recruiting now. Last updated 15 April 2026.

Last reviewed 2026-04-15 · How we verify

NCT03286335

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

Recruiting now NA Last updated 15 April 2026

What this trial tests

NA trial testing Proton Radiation in Brain Tumor in 100 participants. Currently enrolling.

Timeline

26 September 2018

Primary endpoint
30 September 2027

30 September 2027

Quick facts

Lead sponsor	Massachusetts General Hospital
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	100
Start date	26 September 2018
Primary completion	30 September 2027
Estimated completion	30 September 2027
Sites	1 location across United States

Drugs / interventions tested

Proton Radiation

Conditions studied

Brain Tumor — all drugs for Brain Tumor →

Sponsor

Massachusetts General Hospital

Who can join

18 and older, any sex, with Brain Tumor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research study is studying Proton Radiation as a possible treatment for brain tumor. The radiation involved in this study is: -Proton Radiation

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Proton beam therapy for cancer in the era of precision medicine.
Hu M, Jiang L, Cui X, Zhang J, et al · · 2018 · cited 57× · PMID 30541578 · DOI 10.1186/s13045-018-0683-4
Unique brain injury patterns after proton vs photon radiotherapy for WHO grade 2-3 gliomas.
Winter SF, Gardner MM, Karschnia P, Vaios EJ, et al · · 2024 · cited 8× · PMID 39126664 · DOI 10.1093/oncolo/oyae195
Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy.
Winter SF, Vaios EJ, Shih HA, Grassberger C, et al · · 2023 · cited 8× · PMID 37728819 · DOI 10.1007/s11864-023-01131-x

Verify or expand the search:

Other trials of Proton Radiation

Trials testing the same drug.

NCT03164460 — Stereotactic Body Radiation Therapy or Intensity Modulated Radiation/Proton Therapy in Treating Patients With Recurrent · Phase 2 · suspended
NCT01683422 — Chemotherapy Plus Proton-chemotherapy for Locally Advanced Pancreatic Cancer · NA · terminated
NCT01117844 — Proton Radiation For Meningiomas and Hemangiopericytomas · Phase 1, PHASE2 · completed
NCT00831623 — Study of Hypofractionated Proton Beam Radiation Therapy for Prostate Cancer · NA · completed

Other recruiting trials for Brain Tumor

Currently open trials in the same condition.

NCT07224503 — C-SMART vs BE Well for Patients With Brain Tumors · NA · recruiting
NCT07323966 — Feasibility of Mask-Free Radiotherapy for Brain Tumor Patients · NA · recruiting
NCT07122752 — Feasibility and Outcomes of 3D-printed External Cranial Orthosis After Craniectomy · active not recruiting
NCT07105358 — Visual Plasticity Following Brain Lesions · NA · recruiting
NCT06810544 — Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss · Phase 1, PHASE2 · recruiting

Other Massachusetts General Hospital trials

Trials by the same sponsor.

NCT03585946 — Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis · withdrawn
NCT07214831 — A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerg · NA · not yet recruiting
NCT06686901 — A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior · NA · not yet recruiting
NCT05854212 — Behavioral Economics to Implement Nutrition Ranking in Food Pantries · NA · not yet recruiting
NCT07323446 — The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation · EARLY_PHASE1 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03286335 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
Last refreshed: 15 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03286335.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing