NCT03284216 (GlucotoxEx) is a NA clinical trial of Steady-state hyperglycemia in Aerobic Exercise, sponsored by University of Birmingham.

Who is sponsoring NCT03284216?

NCT03284216 is sponsored by University of Birmingham.

What drugs are being tested in NCT03284216?

Interventions in NCT03284216: Steady-state hyperglycemia, Fluctuating hyperglycemia, Exercise.

What condition does NCT03284216 study?

NCT03284216 studies Aerobic Exercise, Hyperglycemia, Glucose Metabolism Disorders (Including Diabetes Mellitus).

Is NCT03284216 still recruiting?

NCT03284216 is currently completed. Last updated 11 December 2018.

Last reviewed 2018-12-11 · How we verify

NCT03284216: GlucotoxEx

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hyperglycemia and Exercise.

Completed NA Last updated 11 December 2018

What this trial tests

NA trial testing Steady-state hyperglycemia in Aerobic Exercise in 12 participants. Completed in 8 December 2018.

Timeline

1 August 2017

Primary endpoint
30 November 2018

8 December 2018

Quick facts

Lead sponsor	University of Birmingham
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	12
Start date	1 August 2017
Primary completion	30 November 2018
Estimated completion	8 December 2018
Sites	1 location across United Kingdom

Drugs / interventions tested

Steady-state hyperglycemia
Fluctuating hyperglycemia
Exercise

Conditions studied

Aerobic Exercise — all drugs for Aerobic Exercise →
Hyperglycemia — all drugs for Hyperglycemia →
Glucose Metabolism Disorders (Including Diabetes Mellitus) — all drugs for Glucose Metabolism Disorders (Including Diabetes Mellitus) →

Sponsor

University of Birmingham

Who can join

Adults 18 to 50, male only, with Aerobic Exercise or Hyperglycemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will determine whether exposure to short-term high blood glucose levels impairs exercise-induced adaptations in glucose tolerance, and whether the pattern of high blood glucose levels plays a role.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans.
Solomon TPJ, Carter S, Haus JM, Karstoft K, et al · · 2022 · cited 9× · PMID 35111398 · DOI 10.7717/peerj.12755
Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals.
Carter S, Solomon TPJ. · · 2020 · cited 5× · PMID 33178135 · DOI 10.3389/fendo.2020.566548

Verify or expand the search:

Other recruiting trials for Aerobic Exercise

Currently open trials in the same condition.

NCT07469540 — Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arth · NA · recruiting
NCT07216495 — Pilot Study of Aerobic Exercise During Immune Checkpoint Inhibitor Therapy in Early-Stage TNBC · NA · recruiting
NCT07002125 — Whole Body Vibration Therapy in Individuals With Type 2 Diabetes · NA · recruiting
NCT07070791 — Combined Upper Extremity Resistance and Aerobic Exercise Training in Patients With Breast Cancer · NA · recruiting
NCT07070778 — Arterial Stiffness in Individuals With Breast Cancer · NA · recruiting

Other University of Birmingham trials

Trials by the same sponsor.

NCT07160686 — Apixaban to Prevent Venous Thromboembolism in Ambulatory Lung Cancer Patients Undergoing Systemic Anticancer Treatment · Phase 3 · not yet recruiting
NCT07446166 — TETANUS Antibody Detection in Saliva Study · NA · not yet recruiting
NCT07294794 — Personalised Pharmacometabolomic-guided Strategy Trial to Optimise Treatment for Hypertension · NA · not yet recruiting
NCT07246356 — Feasibility and Efficacy of GTEP for Birth Trauma · NA · recruiting
NCT06932653 — Reducing Deaths After Surgery in Low- and Middle-income Countries: A Pilot Cluster Randomised Trial · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03284216 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Birmingham
Last refreshed: 11 December 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03284216.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing