Last reviewed · How we verify
Sleep Aging and Risk for Alzheimer's 2.0 (SARA)
Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly. We will directly interrogate the brain using a 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at the 24-month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, the group that could profit the most from sleep preventive strategies.
Details
| Lead sponsor | NYU Langone Health |
|---|---|
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 158 |
| Start date | Tue May 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Dec 25 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Alzheimer Disease
- Sleep Apnea
Interventions
- PET Scan and nocturnal polysomnography
Countries
United States