Who is sponsoring NCT03272399?

NCT03272399 is sponsored by Uniformed Services University of the Health Sciences.

What drugs are being tested in NCT03272399?

Interventions in NCT03272399: Diet/nutrition intervention.

What condition does NCT03272399 study?

NCT03272399 studies Post-Traumatic Headache Chronic Without Intractable Headache.

Is NCT03272399 still recruiting?

NCT03272399 is currently status unknown. Last updated 5 October 2021.

Last reviewed 2021-10-05 · How we verify

NCT03272399

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Nutrition for Post-Traumatic Headache

Status unknown Phase 2 Last updated 5 October 2021

What this trial tests

Phase 2 trial testing Diet/nutrition intervention in Post-Traumatic Headache Chronic Without Intractable Headache in 300 participants. Status unknown.

Timeline

21 August 2017

Primary endpoint
31 March 2022

31 March 2022

Quick facts

Lead sponsor	Uniformed Services University of the Health Sciences
Phase	Phase 2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	300
Start date	21 August 2017
Primary completion	31 March 2022
Estimated completion	31 March 2022
Sites	3 locations across United States

Drugs / interventions tested

Diet/nutrition intervention

Conditions studied

Post-Traumatic Headache Chronic Without Intractable Headache — all drugs for Post-Traumatic Headache Chronic Without Intractable Headache →

Sponsor

Uniformed Services University of the Health Sciences

Who can join

18 and older, any sex, with Post-Traumatic Headache Chronic Without Intractable Headache. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this multi-site study is to evaluate the efficacy of a high omega-3/low omega-6 dietary intervention (the H3-L6 Diet) vs. a Control Diet in reducing headache pain and improving function in soldiers, veterans and military healthcare beneficiaries with post-traumatic headache (PTH). In addition, the study will examine the effects of the diet interventions on anti-nociceptive and pro-nociceptive lipid mediators derived from omega-3 and omega-6 fatty acids.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Identifying oxidized lipid mediators as prognostic biomarkers of chronic posttraumatic headache.
Domenichiello AF, Jensen JR, Zamora D, Horowitz M, et al · · 2020 · cited 14× · PMID 32694380 · DOI 10.1097/j.pain.0000000000001983
Targeted dietary interventions to reduce pain in persistent post-traumatic headache among service members: Protocol for a randomized, controlled parallel-group trial.
Faurot KR, Cole WR, MacIntosh BA, Dunlap M, et al · · 2022 · cited 4× · PMID 35842107 · DOI 10.1016/j.cct.2022.106851
A High Omega-3, Low Omega-6 Diet Reduces Headache Frequency and Intensity in Persistent Post-Traumatic Headache: A Randomized Trial.
Zamora D, Kenney K, Horowitz M, Cole WR, et al · · 2025 · cited 2× · PMID 40600308 · DOI 10.1089/neu.2025.0126
Biochemical and behavioral effects of decreasing dietary linoleic acid and increasing eicosapentaenoic acid and docosahexaenoic acid in a rat chronic monoarthrits model.
Domenichiello AF, Wilhite BC, Nara P, Pitcher MH, et al · · 2022 · cited 2× · PMID 36347090 · DOI 10.1016/j.plefa.2022.102512

Verify or expand the search:

Other Uniformed Services University of the Health Sciences trials

Trials by the same sponsor.

NCT07404787 — Evaluation of a Telehealth Case Management Intervention to Prevent Suicide Among Soldiers Discharged From Psychiatric Ho · NA · recruiting
NCT07050238 — Evaluation of a Group-based, Skills Training for Increasing Mental Toughness · NA · recruiting
NCT07286955 — Life Skills Training for Soldiers Arriving at Their First Duty Location · NA · recruiting
NCT07121452 — Telehealth for Sleep Apnea: Effectiveness, Implementation, and Cost in the Military Health System · NA · recruiting
NCT07267819 — Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03272399 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Uniformed Services University of the Health Sciences
Last refreshed: 5 October 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03272399.

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