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NCT03272061
Exercise and Brain Vascular Function
NA trial testing Aerobic-based exercise program in Physical Exercise in 19 participants. Completed in 31 December 2018.
31 December 2018
Quick facts
| Lead sponsor | Maastricht University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 19 |
| Start date | 1 December 2017 |
| Primary completion | 31 December 2018 |
| Estimated completion | 31 December 2018 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Aerobic-based exercise program
Conditions studied
- Physical Exercise — all drugs for Physical Exercise →
- Cerebrovascular Function — all drugs for Cerebrovascular Function →
- Cerebral Blood Flow — all drugs for Cerebral Blood Flow →
- Glucose Metabolism — all drugs for Glucose Metabolism →
Sponsor
Maastricht University Medical Center
Who can join
Adults 60 to 70, male only, with Physical Exercise or Cerebrovascular Function. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function. Supported by the statement from the American Heart and Stroke Association that physical exercise is one of the most effective strategies to protect against cognitive decline, we now hypothesize that exercise-induced changes in glucose metabolism cause beneficial effects on brain vascular function thereby improving cognitive performance. The primary objective of this intervention study is thus to evaluate in sedentary elderly men the effect of a 8-week aerobic-based exercise program on cerebral blood flow, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI) perfusion method Arterial Spin Labeling (ASL). Cerebral blood flow is a robust and sensitive physiological marker of brain vascular function. Secondary objectives are to examine effects on glucose metabolism using the oral glucose tolerance test and cognitive performance as assessed with a neurophysiological test battery.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Aerobic Exercise Training Improves Cerebral Blood Flow and Executive Function: A Randomized, Controlled Cross-Over Trial in Sedentary Older Men.
Kleinloog JPD, Mensink RP, Ivanov D, Adam JJ, et al · · 2019 · cited 119× · PMID 31866855 · DOI 10.3389/fnagi.2019.00333 -
Aerobic exercise training improves not only brachial artery flow-mediated vasodilatation but also carotid artery reactivity: A randomized controlled, cross-over trial in older men.
Kleinloog JPD, Mensink RP, Roodt JO, Thijssen DHJ, et al · · 2022 · cited 11× · PMID 36030401 · DOI 10.14814/phy2.15395 -
Effects of an 8-week aerobic exercise program on plasma markers for cholesterol absorption and synthesis in older overweight and obese men.
Mashnafi S, Plat J, Mensink RP, Joris PJ, et al · · 2021 · cited 2× · PMID 34548089 · DOI 10.1186/s12944-021-01537-2
Verify or expand the search:
- PubMed search for NCT03272061
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Maastricht University Medical Center trials
Trials by the same sponsor.
- NCT04603261 — Time to Excretion of Contrast, a Maastricht Prospective Observational Study · withdrawn
- NCT04598516 — Maastricht Investigation of Renal Function in Absence of- and Post- Contrast in Patients With eGFR LEss Than 30 · withdrawn
- NCT04597892 — Efficacy of Point-Of-Care Creatinine Assays in Patients With eGFR <30 Receiving Intravascular Contrast · withdrawn
- NCT07287358 — Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II · NA · not yet recruiting
- NCT07501780 — Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03272061 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Maastricht University Medical Center
- Last refreshed: 16 January 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03272061.
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