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NCT03269747: GlucoBAT

Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans

Completed Phase 4 Last updated 5 June 2019
What this trial tests

Phase 4 trial testing Prednisone in Brown Adipose Tissue in 16 participants. Completed in 16 April 2019.

Timeline
6 December 2017
Primary endpoint
16 April 2019
16 April 2019

Quick facts

Lead sponsorUniversity Hospital, Basel, Switzerland
PhasePhase 4
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designcrossover
Maskingquadruple
Primary purposebasic science
Enrollment16
Start date6 December 2017
Primary completion16 April 2019
Estimated completion16 April 2019
Sites1 location across Switzerland

Drugs / interventions tested

Conditions studied

Sponsor

University Hospital, Basel, Switzerland

Who can join

Adults 18 to 40, male only, with Brown Adipose Tissue. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Interventional, Placebo controlled cross-over study to investigate the short-term effects of glucocorticoids (prednisone) on human brown adipose tissue.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Small molecules for fat combustion: targeting obesity.
    Liu J, Wang Y, Lin L. · · 2019 · cited 91× · PMID 30976490 · DOI 10.1016/j.apsb.2018.09.007
  2. The evolving view of thermogenic fat and its implications in cancer and metabolic diseases.
    Yin X, Chen Y, Ruze R, Xu R, et al · · 2022 · cited 43× · PMID 36114195 · DOI 10.1038/s41392-022-01178-6
  3. Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men.
    Maushart CI, Sun W, Othman A, Ghosh A, et al · · 2023 · cited 10× · PMID 37659283 · DOI 10.1016/j.ebiom.2023.104771
  4. Comparison of [<sup>18</sup>F]FDG PET/CT with magnetic resonance imaging for the assessment of human brown adipose tissue activity.
    Fischer JGW, Maushart CI, Becker AS, Müller J, et al · · 2020 · cited 10× · PMID 32699996 · DOI 10.1186/s13550-020-00665-7
  5. Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals.
    Maushart CI, Senn JR, Loeliger RC, Kraenzlin ME, et al · · 2021 · cited 7× · PMID 34194392 · DOI 10.3389/fendo.2021.666595
  6. Clinical Application Potential of Small Molecules that Induce Brown Adipose Tissue Thermogenesis by Improving Fat Metabolism.
    Lu KY, Primus Dass KT, Tsai SF, Chuang HM, et al · · 2020 · cited 2× · PMID 32854518 · DOI 10.1177/0963689720927394
  7. Predicting standardized uptake value of brown adipose tissue from CT scans using convolutional neural networks.
    Erdil E, Becker AS, Schwyzer M, Martinez-Tellez B, et al · · 2024 · cited 1× · PMID 39333526 · DOI 10.1038/s41467-024-52622-w
  8. Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health
    Liu Y, Ding Y, Qiu H, Che Y, et al · · 2026

Verify or expand the search:

Other trials of Prednisone

Trials testing the same drug.

Other recruiting trials for Brown Adipose Tissue

Currently open trials in the same condition.

Other University Hospital, Basel, Switzerland trials

Trials by the same sponsor.

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