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Risk of Chronic Diseases in Young Adults Born Preterm: Relationship With Inflammation and Oxidative Stress Biomarkers.
The purpose of the HAPI project is to study the overall health of preterm infants once they reach adulthood. The investigators would like to compare the health of adults born preterm with that of adults born full-term. They would also like to find the early signs, or biomarkers, of chronic diseases such as high blood pressure, diabetes, osteoporosis, and chronic lung diseases. Such biomarkers would allow for early diagnosis and prevention. Furthermore, the investigators would like to understand why some people born preterm are more likely to develop chronic disease. They believe that inflammation and oxidative stress may play a part. Oxidative stress is present when the body is not able to defend itself against oxygen-derived products that can damage our cells. To carry out this study, the investigators will examine 6 aspects of the health: (1) heart and circulation, (2) kidneys, (3) lungs, (4) metabolism - sugars and fats in the blood, (5) bones, and (6) eyes.
Details
| Lead sponsor | St. Justine's Hospital |
|---|---|
| Status | COMPLETED |
| Enrolment | 200 |
| Start date | Thu Dec 01 2011 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Sat Apr 29 2017 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Prematurity; Extreme
Interventions
- preterm birth
Countries
Canada