A Study of Genetic Variants Associated With Enalapril-Induced Adverse Drug Reaction and Impact of Pharmacogenomics on First Stroke in Hypertensive Patients Taking Enalapril or Enalapril-Folic Acid Therapy.

NCT03259399 UNKNOWN

Dry cough is the most common adverse reaction of angiotensin converting enzyme, including enalapril, in Chinese population. Clinical observations suggest that the incidence of ACEI-induced dry cough is different between Chinese and other racial groups, however, there is still lack of research data in Chinese. Stroke is the second leading cause of death in the world and leading cause of death in China. Except the known risk factor such as hypertension, high homocysteine level, folic acid deficiency, the impact of genetics should not be ignored. In this study, we will investigate whether there are specific genotypes which may predict the incidence of (1)enalapril-induced dry cough in Chinese and (2)first stroke in hypertensive patients taking enalapril or enalapril-folic acid therapy, so as to provide a basis for developing guidelines on precision medication in enalapril therapy apply to Chinese population.

Details

Lead sponsor	Cui Yimin
Status	UNKNOWN
Enrolment	2200
Start date	2017-08-16
Completion	2020-06

Conditions

• Enalapril Adverse Reaction
• Pharmacogenomics
• Stroke

Interventions

• detection of genotype

Primary outcomes

• Incidence of dry cough — At 2 years
• First Incidence of stroke — At 2 years

Countries

China