NCT03258684 (HYVCTTSSS) is a NA clinical trial of Hydrocortisone, Vitamin C, and Thiamine in Sepsis, sponsored by Zhujiang Hospital.

Who is sponsoring NCT03258684?

NCT03258684 is sponsored by Zhujiang Hospital.

What drugs are being tested in NCT03258684?

Interventions in NCT03258684: Hydrocortisone, Vitamin C, and Thiamine, Normal saline.

Is NCT03258684 still recruiting?

NCT03258684 is currently completed. Last updated 12 March 2019.

Last reviewed 2019-03-12 · How we verify

NCT03258684: HYVCTTSSS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock

Completed NA Last updated 12 March 2019

What this trial tests

NA trial testing Hydrocortisone, Vitamin C, and Thiamine in Sepsis in 80 participants. Completed in 2 February 2019.

Timeline

25 September 2017

Primary endpoint
2 February 2019

2 February 2019

Quick facts

Lead sponsor	Zhujiang Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	80
Start date	25 September 2017
Primary completion	2 February 2019
Estimated completion	2 February 2019
Sites	1 location across China

Drugs / interventions tested

Hydrocortisone, Vitamin C, and Thiamine — full drug profile →
Normal saline

Conditions studied

Sepsis — all drugs for Sepsis →

Sponsor

Zhujiang Hospital

Who can join

18 and older, any sex, with Sepsis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this prospective clinical study, the investigators compare the outcome and clinical course of consecutive septic participants treated with intravenous vitamin C, hydrocortisone, and thiamine (treatment group) with a control group treated in the investigators' ICU. The primary outcome is hospital survival. A propensity score is generated to adjust the primary outcome.There is 70 participants in each group.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Combined Treatment With Hydrocortisone, Vitamin C, and Thiamine for Sepsis and Septic Shock: A Randomized Controlled Trial.
Chang P, Liao Y, Guan J, Guo Y, et al · · 2020 · cited 100× · PMID 32243943 · DOI 10.1016/j.chest.2020.02.065
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation.
Moskowitz A, Andersen LW, Huang DT, Berg KM, et al · · 2018 · cited 91× · PMID 30373647 · DOI 10.1186/s13054-018-2217-4
Corticosteroids for treating sepsis in children and adults.
Annane D, Bellissant E, Bollaert PE, Briegel J, et al · · 2019 · cited 76× · PMID 31808551 · DOI 10.1002/14651858.cd002243.pub4
The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.
Hager DN, Hooper MH, Bernard GR, Busse LW, et al · · 2019 · cited 47× · PMID 30953543 · DOI 10.1186/s13063-019-3254-2
Endothelial Activation and Microcirculatory Disorders in Sepsis.
Raia L, Zafrani L. · · 2022 · cited 34× · PMID 35721048 · DOI 10.3389/fmed.2022.907992
Doctor-your septic patients have scurvy!
Marik PE, Hooper MH. · · 2018 · cited 26× · PMID 29378661 · DOI 10.1186/s13054-018-1950-z
Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir.
Obi J, Pastores SM, Ramanathan LV, Yang J, et al · · 2020 · cited 19× · PMID 32061462 · DOI 10.1016/j.jcrc.2019.12.011
Steroids for sepsis: yes, no or maybe.
Marik PE. · · 2018 · cited 12× · PMID 29849191 · DOI 10.21037/jtd.2018.04.35

Verify or expand the search:

Other recruiting trials for Sepsis

Currently open trials in the same condition.

NCT07507877 — Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness · recruiting
NCT07154615 — Assessing Immune Dysfunction in Sepsis · recruiting
NCT07419802 — OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study · recruiting
NCT07351344 — African Survey on Sepsis Knowledge (ASK) · recruiting
NCT07448805 — Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit · NA · recruiting

Other Zhujiang Hospital trials

Trials by the same sponsor.

NCT07335094 — A Clinical Study of Humanized CD19 CAR-T Cells With TLR2 for the Treatment of Adult Patients With Naive B-Cell Acute Lym · EARLY_PHASE1 · not yet recruiting
NCT07469072 — Comparison of Anticoagulant Effects of Different Doses of Nafamostat in Continuous Renal Replacement Therapy (CRRT) in t · Phase 2 · recruiting
NCT07455149 — An Observational Clinical Study on the Association of Intestinal Ruminococcus Gnavus and Its Derived Biogenic Amines Wit · not yet recruiting
NCT07457099 — Impact of Postoperative Radiotherapy Versus PD-1 Inhibitor Maintenance on Survival in Resectable Locally Advanced Oral a · not yet recruiting
NCT07454421 — Racecadotril for Organ Injury in Sepsis Patients · Phase 1, PHASE2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03258684 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Zhujiang Hospital
Last refreshed: 12 March 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03258684.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing