Who is sponsoring NCT03256396?

NCT03256396 is sponsored by Mahidol University.

What drugs are being tested in NCT03256396?

Interventions in NCT03256396: PEEP setting based on esophageal pressure measured.

What condition does NCT03256396 study?

NCT03256396 studies Positive-Pressure Respiration/Methods, Esophagus/Physiopathology, Pleura/Physiopathology, Gynecologic Surgical Procedures, Laparoscopy, Humans, Female.

Is NCT03256396 still recruiting?

NCT03256396 is currently completed. Last updated 22 August 2019.

Last reviewed 2019-08-22 · How we verify

NCT03256396

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intraoperative PEEP Setting During Laparoscopic Gynecologic Surgery

Completed NA Last updated 22 August 2019

What this trial tests

NA trial testing PEEP setting based on esophageal pressure measured in Positive-Pressure Respiration/Methods in 44 participants. Completed in 28 December 2018.

Timeline

30 March 2018

Primary endpoint
29 June 2018

28 December 2018

Quick facts

Lead sponsor	Mahidol University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	44
Start date	30 March 2018
Primary completion	29 June 2018
Estimated completion	28 December 2018
Sites	1 location across Thailand

Drugs / interventions tested

PEEP setting based on esophageal pressure measured

Conditions studied

Positive-Pressure Respiration/Methods — all drugs for Positive-Pressure Respiration/Methods →
Esophagus/Physiopathology — all drugs for Esophagus/Physiopathology →
Pleura/Physiopathology — all drugs for Pleura/Physiopathology →
Gynecologic Surgical Procedures — all drugs for Gynecologic Surgical Procedures →

Sponsor

Mahidol University

Who can join

18 and older, female only, with Positive-Pressure Respiration/Methods or Esophagus/Physiopathology. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The creation of pneumoperitoneum during laparoscopic surgery can have significant effects on the respiratory system including decreased respiratory system compliance, decreased vital capacity and functional residual capacity and atelectasis formation. Intraoperative mechanical ventilation, especially setting of positive end-expiratory pressure (PEEP) has an important role in respiratory management during laparoscopic surgery. The aim of this study is to determine whether setting of PEEP guided by measurement of pleural pressure would improve oxygenation and respiratory system compliance during laparoscopic surgery.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Perioperative lung protective ventilation.
O'Gara B, Talmor D. · · 2018 · cited 75× · PMID 30201797 · DOI 10.1136/bmj.k3030
Effects of intra-operative positive end-expiratory pressure setting guided by oesophageal pressure measurement on oxygenation and respiratory mechanics during laparoscopic gynaecological surgery: A randomised controlled trial.
Piriyapatsom A, Phetkampang S. · · 2020 · cited 13× · PMID 32371830 · DOI 10.1097/eja.0000000000001204

Verify or expand the search:

Other Mahidol University trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03256396 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mahidol University
Last refreshed: 22 August 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03256396.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing