NCT03256240 is a NA clinical trial of side-to-side functional end anastomosis in Crohn's Disease, sponsored by Weill Medical College of Cornell University.

Who is sponsoring NCT03256240?

NCT03256240 is sponsored by Weill Medical College of Cornell University.

What drugs are being tested in NCT03256240?

Interventions in NCT03256240: side-to-side functional end anastomosis, Kono-S analstomosis.

What condition does NCT03256240 study?

NCT03256240 studies Crohn's Disease.

Is NCT03256240 still recruiting?

NCT03256240 is currently recruiting now. Last updated 7 April 2026.

Last reviewed 2026-04-07 · How we verify

NCT03256240

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis

Recruiting now NA Last updated 7 April 2026

What this trial tests

NA trial testing side-to-side functional end anastomosis in Crohn's Disease in 600 participants. Currently enrolling.

Timeline

12 March 2014

Primary endpoint
31 July 2030

31 December 2036

Quick facts

Lead sponsor	Weill Medical College of Cornell University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	600
Start date	12 March 2014
Primary completion	31 July 2030
Estimated completion	31 December 2036
Sites	15 locations across Italy, Finland, Belgium, Germany, United States, Spain

Drugs / interventions tested

side-to-side functional end anastomosis
Kono-S analstomosis

Conditions studied

Crohn's Disease — all drugs for Crohn's Disease →

Sponsor

Weill Medical College of Cornell University

Who can join

Adults 18 to 90, any sex, with Crohn's Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study proposes a randomized prospective study comparing the Kono-S anastomosis to the standard side-to-side anastomosis.This will be a multi-center randomized prospective trial. Patients with Crohn's ileitis or Crohn's ileocolitis requiring resection will be randomized to undergo either the Kono-S anastomosis or the side-to-side functional end anastomosis.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Surgical Treatment for Crohn's Disease: A Role of Kono-S Anastomosis in the West.
Kono T, Fichera A. · · 2020 · cited 27× · PMID 33162837 · DOI 10.1055/s-0040-1714236
Recent trends (2016-2017) in the treatment of inflammatory bowel disease.
Masaki T, Kishiki T, Kojima K, Asou N, et al · · 2018 · cited 21× · PMID 30003191 · DOI 10.1002/ags3.12177
Surgical Techniques and Risk of Postoperative Recurrence in CD: A Game Changer?
Luglio G, Kono T. · · 2022 · cited 15× · PMID 35224014 · DOI 10.1159/000515372
The Revival of Surgery in Crohn's Disease-Early Intestinal Resection as a Reasonable Alternative in Localized Ileitis.
Kelm M, Germer CT, Schlegel N, Flemming S. · · 2021 · cited 12× · PMID 34680434 · DOI 10.3390/biomedicines9101317
Surgical Strategies to Reduce Postoperative Recurrence of Crohn's Disease After Ileocolic Resection.
Reynolds IS, Doogan KL, Ryan ÉJ, Hechtl D, et al · · 2021 · cited 6× · PMID 34977147 · DOI 10.3389/fsurg.2021.804137
Effect of extensive mesenteric excision on primary ileocolic resection outcomes in Crohn's disease patients: a systematic review with meta-analysis.
Martínez-Pérez A, Schena CA, Pellino G, Martínez-López E, et al · · 2025 · PMID 41329358 · DOI 10.1007/s00384-025-05043-0

Verify or expand the search:

Other recruiting trials for Crohn's Disease

Currently open trials in the same condition.

NCT07273188 — 68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease · EARLY_PHASE1 · recruiting
NCT07184944 — A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Acti · Phase 3 · recruiting
NCT07242248 — A Study to Observe Real-world Evidence of Guselkumab Treatment in Participants With Ulcerative Colitis and Crohn's Disea · recruiting
NCT06405087 — A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD · Phase 3 · recruiting
NCT07184931 — An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Activ · Phase 3 · recruiting

Other Weill Medical College of Cornell University trials

Trials by the same sponsor.

NCT07485712 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2 · NA · not yet recruiting
NCT05811338 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1 · NA · not yet recruiting
NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
NCT06818734 — Implementation of a Clinical Decision Support Tool for Postpartum Depression · NA · not yet recruiting
NCT07485725 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 3 · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03256240 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Weill Medical College of Cornell University
Last refreshed: 7 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03256240.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing