NCT03252184

Effects of Photobiomodulation on Endothelial Function in Healthy Subjects

Status unknown NA Last updated 24 March 2020

What this trial tests

NA trial testing Low level laser therapy - 1 in Healthy Behavior in 16 participants. Status unknown.

Timeline

1 September 2017

Primary endpoint
30 December 2019

30 December 2020

Quick facts

Lead sponsor	Rodrigo Della Méa Plentz
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	16
Start date	1 September 2017
Primary completion	30 December 2019
Estimated completion	30 December 2020
Sites	1 location across Brazil

Drugs / interventions tested

• Low level laser therapy - 1
• Low level laser therapy - 2
• Low level laser therapy - 3

Conditions studied

• Healthy Behavior — all drugs for Healthy Behavior →

Sponsor

Rodrigo Della Méa Plentz

Who can join

Adults 18 to 40, any sex, with Healthy Behavior. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The endothelial cell layer is responsible for the control of vascular homeostasis, a process mediated by vasoconstricting and vasodilatory substances. The principal endothelium-dependent vascular dilator is nitric oxide (NO), and the reduction of its synthesis or bioavailability is the main cause for the development of endothelial dysfunction. The use of photobiomodulation may be beneficial in several clinical situations. At the endothelial level, the stimulatory effects on vascular endothelial growth factor, NO secretion, number of capillaries and proliferation of endothelial cells are outstanding. The objective of this study is to evaluate the effects of photobiomodulation on the arterial endothelial function of healthy individuals. The study design will be a randomized, crossover, clinical trial and the sample will be composed of subjects selected by the eligibility criteria, and randomly randomized according to the order of intervention of the groups. The hypothesis is that at the end of the protocol with photobiomodulation an increase in endothelial function and blood markers of endothelial function occurs, and no tissue temperature variation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effects of photobiomodulation therapy (PBMT) over endothelial function in healthy individuals: a preliminary crossover clinical trial.
   Hauck M, Schardong J, Donini G, Normann TC, et al · · 2023 · cited 3× · PMID 37072603 · DOI 10.1007/s10103-023-03762-w