DOuble SEquential External Defibrillation for Refractory VF Pilot Study (DOSE-VF)

NCT03249948 NA COMPLETED

Despite significant advances in resuscitation efforts, there are some patients who remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest. Double sequential external defibrillation (DSED) and vector change defibrillation have been proposed as a viable option for patients in refractory VF. This pilot cluster randomized trial will compare (1) continued resuscitation using standard defibrillation; (2) resuscitation involving DSED; or (3) resuscitation involving vector change defibrillation, in patients presenting with refractory VF during out-of-hospital cardiac arrest. The results of this pilot study will provide critical data for planning a larger, adequately powered multi-site randomized controlled trial to clinically evaluate DSED and vector change defibrillation compared to standard therapy for patients in refractory VF.

Details

Lead sponsor	Sunnybrook Health Sciences Centre
Phase	NA
Status	COMPLETED
Enrolment	173
Start date	Mon Mar 05 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu Mar 12 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Ventricular Fibrillation

Interventions

• Vector change defibrillation
• Double-sequential defibrillation

Countries

Canada