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NCT03248076
Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.
trial testing Fentanyl Citrate in Stress Reaction in 30 participants. Status unknown.
31 August 2018
Quick facts
| Lead sponsor | George Papanicolaou Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 1 April 2017 |
| Primary completion | 31 August 2018 |
| Estimated completion | 10 October 2018 |
| Sites | 1 location across Greece |
Drugs / interventions tested
- Fentanyl Citrate — full drug profile →
Conditions studied
- Stress Reaction — all drugs for Stress Reaction →
- Opioid Use — all drugs for Opioid Use →
Sponsor
George Papanicolaou Hospital
Who can join
Adults 18 to 32, female only, with Stress Reaction or Opioid Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via OPRM1, causing ovarian hyperstimulation syndrome. This study aims to investigate if a single exposure to opioids is enough to produce activation of stress mechanism during oocyte retrieval.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT03248076
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03248076 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by George Papanicolaou Hospital
- Last refreshed: 14 December 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03248076.
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