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NCT03246451
The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D
NA trial testing Placebo Oral Tablet in Glucose Metabolism Disorders in 15 participants. Completed in 10 December 2017.
10 December 2017
Quick facts
| Lead sponsor | University Hospital, Gentofte, Copenhagen |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 15 |
| Start date | 1 July 2017 |
| Primary completion | 10 December 2017 |
| Estimated completion | 10 December 2017 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Placebo Oral Tablet — full drug profile →
- Metformin (metformin) — full drug profile →
- Saline
- Exendin (9-39)
Conditions studied
- Glucose Metabolism Disorders — all drugs for Glucose Metabolism Disorders →
Sponsor
University Hospital, Gentofte, Copenhagen
Who can join
18 and older, any sex, with Glucose Metabolism Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Delineation of the role of glucagon-like peptide-1 receptor signalling in the glucose-lowering effect of metformin during meal ingestion in patients with type 2 diabetes.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The role of glucagon-like peptide 1 in the postprandial effects of metformin in type 2 diabetes: a randomized crossover trial.
Hansen LS, Gasbjerg LS, Brønden A, Dalsgaard NB, et al · · 2024 · cited 5× · PMID 39049802 · DOI 10.1093/ejendo/lvae095
Verify or expand the search:
- PubMed search for NCT03246451
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Glucose Metabolism Disorders
Currently open trials in the same condition.
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- NCT06878781 — Postprandial Metabolome and Metabolic Flexibility · NA · recruiting
Other University Hospital, Gentofte, Copenhagen trials
Trials by the same sponsor.
- NCT07171723 — Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment · Phase 1, PHASE2 · recruiting
- NCT06934473 — Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals · NA · recruiting
- NCT06845033 — Effects of Antagonizing the Ghrelin Receptor on Brain Food Cue Reactivity in Obesity · NA · not yet recruiting
- NCT06787001 — Understanding How Gut and Brain Barriers Are Linked to Inflammation in Obesity · completed
- NCT06881459 — The Effect of Oxytocin on the Alpha Cell Response to Hypoglycaemia in Patients With Type 1 Diabetes · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03246451 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Gentofte, Copenhagen
- Last refreshed: 9 July 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03246451.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing