The Impact of Heart Rate on Central Hemodynamics in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker

NCT03245996 Phase 4 COMPLETED

This study is divided into two parts: * The first part evaluates the acute effect of non-pharmacological heart rate change on central hemodynamic parameters noninvasively in sick sinus syndrome patients with a permanent cardiac pacemaker * The second part evaluates the acute effects of atenolol, nebivolol and ivabradine on central hemodynamic parameters noninvasively in sick sinus syndrome patients with a permanent cardiac pacemaker at different pacing rate levels

Details

Lead sponsor	Tartu University Hospital
Phase	Phase 4
Status	COMPLETED
Enrolment	27
Start date	2015-06
Completion	2016-09

Conditions

• Aortic Blood Pressure

Interventions

• AAI 40 bpm
• AAI 60 bpm
• AAI 90 bpm
• Atenolol Pill
• Nebivolol Pill
• Ivabradine Pill

Primary outcomes

• First part of the study: central systolic blood pressure — 3 minutes after heart rate change
• Second part of the study: systolic blood pressure amplification — 3 hours after drug administration and 3 minutes after heart rate change
  difference between peripheral and central systolic blood pressure