NCT03245723: PET-MRI

Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)

Completed NA Results posted Last updated 4 February 2021

What this trial tests

NA trial testing Pulmonary Function Testing in Infant,Premature in 52 participants. Completed in 26 February 2020.

Timeline

20 September 2017

Primary endpoint
26 February 2020

26 February 2020

Quick facts

Lead sponsor	University of Wisconsin, Madison
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	52
Start date	20 September 2017
Primary completion	26 February 2020
Estimated completion	26 February 2020
Sites	1 location across United States

Drugs / interventions tested

• Pulmonary Function Testing
• Electrocardiogram
• Positron Emission Tomography
• Magnetic Resonance Imaging

Conditions studied

• Infant,Premature — all drugs for Infant,Premature →

Sponsor

University of Wisconsin, Madison

Who can join

Adults 18 to 35, any sex, with Infant,Premature. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Cardiac Glucose Uptake During Normoxic Rest (µg/Min) Primary · Visit 1 (1 day)

Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.

Group	Value	95% CI
Preterm	0.689	± 0.546
Term - Healthy Controls	0.540	± 0.454

Change in Glucose Uptake From Normoxia to Hypoxia (µg/Min) Primary · Visit 1 (1 day)

Cardiac glucose uptake will be measured via 18F-fluorodeoxyglucose (FDG) PET-MRI.

Group	Value	95% CI
Preterm	-0.264	± 0.588
Term - Healthy Controls	-0.003	± 0.390

Sponsor's own description

The purpose of this research is to determine the effect of premature birth on later heart function and metabolism.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Exaggerated Cardiac Contractile Response to Hypoxia in Adults Born Preterm.
   Barton GP, Corrado PA, Francois CJ, Chesler NC, et al · · 2021 · cited 16× · PMID 33802149 · DOI 10.3390/jcm10061166
2. Diffuse Myocardial Fibrosis at Cardiac MRI in Young Adults Born Prematurely: A Cross-sectional Cohort Study.
   François CJ, Barton GP, Corrado PA, Broman AT, et al · · 2022 · cited 7× · PMID 35833164 · DOI 10.1148/ryct.210224
3. Dynamic FDG PET Imaging to Probe for Cardiac Metabolic Remodeling in Adults Born Premature.
   Corrado PA, Barton GP, Razalan-Krause FC, François CJ, et al · · 2021 · cited 3× · PMID 33809883 · DOI 10.3390/jcm10061301