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NCT03245268
International BPA Registry
trial testing Balloon pulmonary angioplasty in Chronic Thromboembolic Pulmonary Hypertension in 500 participants. Completed in 31 March 2022.
31 March 2022
Quick facts
| Lead sponsor | International CTEPH Association |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 2 March 2018 |
| Primary completion | 31 March 2022 |
| Estimated completion | 31 March 2022 |
| Sites | 18 locations across France, Japan, Netherlands, Belgium, Austria, United Kingdom, Germany, Poland |
Drugs / interventions tested
- Balloon pulmonary angioplasty
Conditions studied
- Chronic Thromboembolic Pulmonary Hypertension — all drugs for Chronic Thromboembolic Pulmonary Hypertension →
- CTEPH — all drugs for CTEPH →
Sponsor
International CTEPH Association
Who can join
Eligibility, any sex, with Chronic Thromboembolic Pulmonary Hypertension or CTEPH. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The International Balloon Pulmonary Angioplasty (BPA) Registry is a prospective, multi-center, long-term observational project. Scheduled to start data collection in Q4 2017, the registry will run for approximately four years with a follow-up time for each patient of at least two years. Its primary objective is to investigate the efficacy and safety of BPA intervention in patients with chronic thromboembolic pulmonary hypertension (CTEPH) not amenable to pulmonary endarterectomy (PEA).
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: a clinical consensus statement of the ESC working group on pulmonary circulation and right ventricular function.
Lang IM, Andreassen AK, Andersen A, Bouvaist H, et al · · 2023 · cited 69× · PMID 37470202 · DOI 10.1093/eurheartj/ehad413 -
Chronic thromboembolic pulmonary disease.
Kim NH, D'Armini AM, Delcroix M, Jaïs X, et al · · 2024 · cited 49× · PMID 39209473 · DOI 10.1183/13993003.01294-2024 -
Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: a multicentre registry.
Darocha S, Roik M, Kopeć G, Araszkiewicz A, et al · · 2022 · cited 41× · PMID 34219663 · DOI 10.4244/eij-d-21-00230 -
Worldwide CTEPH Registry: Long-Term Outcomes With Pulmonary Endarterectomy, Balloon Pulmonary Angioplasty, and Medical Therapy.
Delcroix M, Pepke-Zaba J, D'Armini AM, Fadel E, et al · · 2024 · cited 38× · PMID 39286890 · DOI 10.1161/circulationaha.124.068610 -
Advances in balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.
Mahmud E, Patel M, Ang L, Poch D. · · 2021 · cited 34× · PMID 34104421 · DOI 10.1177/20458940211007385 -
Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: State of the art.
Jin Q, Zhao ZH, Luo Q, Zhao Q, et al · · 2020 · cited 21× · PMID 32742980 · DOI 10.12998/wjcc.v8.i13.2679 -
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Results of an International Multicenter Prospective Registry.
Lang IM, Brenot P, Bouvaist H, Fadel E, et al · · 2025 · cited 7× · PMID 40499982 · DOI 10.1016/j.jacc.2025.04.021 -
Emerging Role of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease-Insights from the 2022 ESC Guidelines.
Banaszkiewicz M, Kurzyna P, Kubikowska N, Mucha M, et al · · 2023 · cited 6× · PMID 37629379 · DOI 10.3390/jcm12165336
Verify or expand the search:
- PubMed search for NCT03245268
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Balloon pulmonary angioplasty
Trials testing the same drug.
- NCT07254078 — Registry of Patients With chrOnic thromboemboLic Pulmonary hypErTension · recruiting
- NCT05110066 — BPA vs. PEA in CTEPH · NA · recruiting
- NCT04444973 — RV Conductance Catheter Assessment During Balloon Pulmonary Angioplasty · unknown
- NCT04206852 — Safety and Efficacy of Balloon Pulmonary Angioplasty in China · recruiting
Other recruiting trials for Chronic Thromboembolic Pulmonary Hypertension
Currently open trials in the same condition.
- NCT07272798 — Cardiac Self-Efficacy in Patients With Chronic Thromboembolic Pulmonary Hypertension · recruiting
- NCT07254078 — Registry of Patients With chrOnic thromboemboLic Pulmonary hypErTension · recruiting
- NCT06922240 — Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART) · Phase 3 · recruiting
- NCT06081881 — Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Embolism · recruiting
- NCT06715280 — Switching of Sildenafil to Riociguat in CTEPH Patients · Phase 4 · recruiting
Other International CTEPH Association trials
Trials by the same sponsor.
- NCT03273257 — Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) · Phase 2 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03245268 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by International CTEPH Association
- Last refreshed: 10 June 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03245268.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing