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NCT03245125
HIIT Improves Survival of Heart Failure Patients
trial testing High-intensity interval training in Heart Failure in 329 participants. Completed in 30 April 2017.
31 December 2016
Quick facts
| Lead sponsor | Chang Gung Memorial Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 329 |
| Start date | 1 January 2009 |
| Primary completion | 31 December 2016 |
| Estimated completion | 30 April 2017 |
Drugs / interventions tested
- High-intensity interval training
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- Cardiac Rehabilitation — all drugs for Cardiac Rehabilitation →
- Cardiac Remodeling, Ventricular — all drugs for Cardiac Remodeling, Ventricular →
Sponsor
Chang Gung Memorial Hospital
Who can join
Adults 20 to 80, any sex, with Heart Failure or Cardiac Rehabilitation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
BACKGROUND Global burdens of heart failure (HF) are increasing in modern societies. High-intensity interval training (HIIT) increases peak oxygen consumption (VO2peak) in HF patients, which was hypothesized to improve the survival of HF patients. OBJECTIVES The cohort study aimed to highlight the effect of HIIT on long-term survivals of HF patients. METHODS 329 HF patients, enrolled between 2009 and 2016, received multidisciplinary disease management program (MDP). They had cardiopulmonary exercise test for peak exercise capacity (VO2peak), echocardiographic examination for left ventricular ejection fraction (LVEF), LV end-diastolic diameter (LVEDD), and LV end-systolic diameter (LVESD), b-type natriuretic peptide (BNP), and quality of life questionnaire. HF patients with LVEF≤ 40% (HFrEF) and HF patients with LVEF\> 40% (HFpEF) underwent≥ 36 times of HIIT. HFrEF and HFpEF patients were classified as the MDP group. Generalized estimating equation (GEE) was used to estimate the interaction between time and VO2peak, LVEF, LVEDD, LVESD, and BNP during the follow-up. Survival analysis was conducted to assess effects of HIIT on the long-term survival of HF during at end of the study.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
High-Intensity Interval Training is Associated with Improved Long-Term Survival in Heart Failure Patients.
Hsu CC, Fu TC, Yuan SS, Wang CH, et al · · 2019 · cited 16× · PMID 30934556 · DOI 10.3390/jcm8030409
Verify or expand the search:
- PubMed search for NCT03245125
- Europe PMC full search
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Related trials
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Other recruiting trials for Heart Failure
Currently open trials in the same condition.
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Other Chang Gung Memorial Hospital trials
Trials by the same sponsor.
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- NCT07036978 — Metabolomic and Immune-Microbiome Profiling for Unresectable Pancreatic Cancer · not yet recruiting
- NCT07489833 — Metabolomic Pathways and Traditional Chinese Medicine Body Constitution in Cancer-related Fatigue · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03245125 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chang Gung Memorial Hospital
- Last refreshed: 10 August 2017
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