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NCT03240250
Randomized Study on Effects of Uniportal VATS Versus Triportal VATS
trial testing VATS uni-portal lobectomy and lymphoadenectomy in Lung Cancer in 120 participants. Completed in 1 October 2020.
1 October 2020
Quick facts
| Lead sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 120 |
| Start date | 12 March 2017 |
| Primary completion | 1 October 2020 |
| Estimated completion | 1 October 2020 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- VATS uni-portal lobectomy and lymphoadenectomy
- VATS three-portal lobectomy and lymphoadenectomy
Conditions studied
- Lung Cancer — all drugs for Lung Cancer →
Sponsor
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Who can join
Adults 30 to 80, any sex, with Lung Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
For the treatment of stage I-II NSCLC, two mini-invasive techniques are mostly utilized: uni-portal and three-portal VATS. In the uniportal approach, the injury on a single intercostal space could determine a lower level of pain than the three-portal approach, allowing a better postoperative course. Few studies in Literature compare these techniques, and most of them are retrospective. The main purpose of this randomized study is to compare uni-portal VATS with three-portal VATS, in terms of postoperative pain. Secondary objectives of the study are valutations of: * respiratory and functional capacity between the two groups * operative time * number of resected lymphnodes * intra and postoperative complications, such as conversions to open surgery, amount of bleeding, prolonged air leaks, surgical site infections, pulmonary complications.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Pulmonary Lobectomy for Early-Stage Lung Cancer with Uniportal versus Three-Portal Video-Assisted Thoracic Surgery: Results from a Single-Centre Randomized Clinical Trial.
Tosi D, Mazzucco A, Musso V, Bonitta G, et al · · 2023 · cited 9× · PMID 38002779 · DOI 10.3390/jcm12227167 -
Uniportal and three-portal video-assisted thoracic surgery pulmonary lobectomy for early-stage lung cancer (UNIT trial): study protocol of a single-center randomized trial.
Mendogni P, Mazzucco A, Palleschi A, Rosso L, et al · · 2021 · cited 9× · PMID 33632284 · DOI 10.1186/s13063-021-05115-w -
Uni-portal and three-portal video-assisted thoracic surgery pulmonary lobectomy for early stage lung cancer (UNIT trial): study protocol of a single-center randomized trial
Mendogni P, Mazzucco A, Palleschi A, Rosso L, et al · · 2021 · DOI 10.21203/rs.3.rs-217068/v1
Verify or expand the search:
- PubMed search for NCT03240250
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03240250 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Last refreshed: 9 February 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03240250.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing