NCT03236376

Brain-behavior Associations of Sensorimotor Therapy Post Stroke

Completed NA Last updated 18 January 2020

What this trial tests

NA trial testing additional sensorimotor therapy for the upper limb in Stroke in 59 participants. Completed in 6 January 2020.

Timeline

21 September 2017

Primary endpoint
1 December 2017

6 January 2020

Quick facts

Lead sponsor	Universitaire Ziekenhuizen KU Leuven
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	59
Start date	21 September 2017
Primary completion	1 December 2017
Estimated completion	6 January 2020
Sites	1 location across Belgium

Drugs / interventions tested

• additional sensorimotor therapy for the upper limb
• additional motor therapy for the upper limb after stroke

Conditions studied

• Stroke — all drugs for Stroke →

Sponsor

Universitaire Ziekenhuizen KU Leuven — full company profile →

Who can join

18 and older, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Stroke survivors often encounter impairments in the upper limb after stroke. Sensorimotor impairments are present in 67% of the stroke patients, resulting in problems with independency and performance of activities of daily life. In addition, the pattern of recovery in the brain is still a matter of ongoing debate. Although the importance of somatosensory function on motor performance is well described, evidence for somatosensory or sensorimotor therapy and brain-related changes is scares. Therefore, we aim to explore the effect of a sensorimotor therapy compared to pure motor therapy on motor function of the upper limb. A second objective is to investigate therapy-induced brain-behavior associations using resting state functional Magnetic Resonance Imaging of the brain.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Sensorimotor vs. Motor Upper Limb Therapy for Patients With Motor and Somatosensory Deficits: A Randomized Controlled Trial in the Early Rehabilitation Phase After Stroke.
   De Bruyn N, Saenen L, Thijs L, Van Gils A, et al · · 2020 · cited 26× · PMID 33343498 · DOI 10.3389/fneur.2020.597666
2. Interventions for perceptual disorders following stroke.
   Hazelton C, Thomson K, Todhunter-Brown A, Campbell P, et al · · 2022 · cited 25× · PMID 36326118 · DOI 10.1002/14651858.cd007039.pub3
3. Brain connectivity alterations after additional sensorimotor or motor therapy for the upper limb in the early-phase post stroke: a randomized controlled trial.
   De Bruyn N, Saenen L, Thijs L, Van Gils A, et al · · 2021 · cited 13× · PMID 33937771 · DOI 10.1093/braincomms/fcab074
4. Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial.
   De Bruyn N, Essers B, Thijs L, Van Gils A, et al · · 2018 · cited 6× · PMID 29678195 · DOI 10.1186/s13063-018-2609-4
5. Sensorimotor upper limb therapy does not improve somatosensory function and may negatively interfere with motor recovery: a randomized controlled trial in the early rehabilitation phase after stroke
   Nele DB, Leen S, Liselot T, Annick VG, et al · · 2020 · DOI 10.1101/2020.09.15.20194845