NCT03229915

CPT-fMRI Study for PTSD

Completed NA Last updated 15 February 2023

What this trial tests

NA trial testing cognitive processing therapy in Stress Disorders, Post-Traumatic in 68 participants. Completed in 30 September 2022.

Timeline

1 October 2017

Primary endpoint
30 September 2022

30 September 2022

Quick facts

Lead sponsor	University of Manitoba
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	68
Start date	1 October 2017
Primary completion	30 September 2022
Estimated completion	30 September 2022
Sites	1 location across Canada

Drugs / interventions tested

• cognitive processing therapy

Conditions studied

• Stress Disorders, Post-Traumatic — all drugs for Stress Disorders, Post-Traumatic →

Sponsor

University of Manitoba

Who can join

18 and older, any sex, with Stress Disorders, Post-Traumatic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Posttraumatic stress disorder (PTSD) is prevalent mental illness (\~9% life-time) that results from exposure to trauma. As it is associated with vastly heterogeneous origins, accurate diagnosis and optimal treatment strategies are sometimes very difficult to achieve. No known biomarker exists, which makes it difficult to assess treatment response and functional outcomes. The recent brain imaging studies have suggested that PTSD patients show abnormal brain connectivity measured by functional magnetic resonance imaging (fMRI). The investigators propose that cognitive processing therapy may ameliorate this functional connectivity abnormality which may be related with their symptomatic improvement.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Investigating neural markers of Alzheimer's disease in posttraumatic stress disorder using machine learning algorithms and magnetic resonance imaging.
   Yakemow G, Kolesar TA, Wright N, Beheshti I, et al · · 2024 · cited 4× · PMID 39574505 · DOI 10.3389/fneur.2024.1470727
2. Understanding false positives in control conditions: a simulation study of <i>post-hoc</i> testing in low-powered neuroimaging trials.
   Ko JH. · · 2025 · PMID 41426613 · DOI 10.3389/fnimg.2025.1637148