Last reviewed · How we verify
NCT03226847
Pulmonary Vein Isolation in Athletes
NA trial testing Pulmonary Vein Isolation in Athletes in 10 participants. Completed in 16 March 2021.
30 June 2020
Quick facts
| Lead sponsor | The Cleveland Clinic |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 10 |
| Start date | 17 July 2017 |
| Primary completion | 30 June 2020 |
| Estimated completion | 16 March 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Pulmonary Vein Isolation
Conditions studied
- Athletes — all drugs for Athletes →
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
- Catheter Ablation — all drugs for Catheter Ablation →
Sponsor
The Cleveland Clinic
Who can join
Adults 18 to 65, any sex, with Athletes or Atrial Fibrillation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pulmonary vein isolation (PVI) has become a common and effective treatment for paroxysmal and persistent atrial fibrillation (AF), particularly in patients with drug-refractory disease. Intense endurance exercise is a known risk factor for atrial fibrillation. In general, these athletes poorly tolerate most common antiarrhythmic drugs used for atrial fibrillation control and often PVI is recommended for durable management. While the efficacy of PVI in athletes is similar to the general AF population, some athletes with lone atrial fibrillation report a reduction in subjective exertional capacity following PVI, despite maintenance of sinus rhythm and absence of pulmonary vein stenosis on imaging. The investigators hypothesize that PVI may alter pulmonary vein function and affect peak exercise performance. The investigators propose a small, prospective study of endurance athletes undergoing antral PVI for treatment of lone atrial fibrillation. Peak metabolic performance and pulmonary vein function will be assessed pre- and post-PVI by metabolic stress testing and cardiac MRI, respectively.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03226847
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Pulmonary Vein Isolation
Trials testing the same drug.
- NCT07380932 — Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair · NA · not yet recruiting
- NCT07238452 — Optimising Pacing Therapy, Integrated Medical Therapy, and Catheter AbLation for Atrial Fibrillation in Heart Failure Tr · Phase 4 · not yet recruiting
- NCT06929897 — PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF · NA · not yet recruiting
- NCT04282850 — Ablation Versus Medical Management of Atrial Fibrillation in HFpEF · NA · terminated
- NCT03835338 — WATCHMAN for Concomitant Left Atrial Appendage Electrical Isolation and Occlusion to Treat Persistent Atrial Fibrillatio · NA · withdrawn
Other recruiting trials for Athletes
Currently open trials in the same condition.
- NCT07133841 — Validity of Thermal Imaging in Injury Risk Assessment in Volleyball Players · recruiting
- NCT06803979 — Impact of Delivery Method Elite Athletes. · recruiting
- NCT05936840 — Quantum Menstrual Health Monitoring Study · recruiting
- NCT06377306 — Identifying Periods of High Training Load Considering the Menstrual Cycle Phases in Elite and Non-elite Female Athletes · recruiting
- NCT06017180 — Effects of Myofascial Release Technique on Mobility, Sensorimotor Function and Performance in Volleyball Players · NA · recruiting
Other The Cleveland Clinic trials
Trials by the same sponsor.
- NCT07218198 — Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension · NA · not yet recruiting
- NCT07442747 — Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS · NA · not yet recruiting
- NCT07471464 — Centered Surgery - Preoperative Counseling and Patient Satisfaction · recruiting
- NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
- NCT07363343 — Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03226847 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
- Last refreshed: 13 December 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03226847.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing