Prevention of Hyperalgesia With Epidural Morphine

NCT03225690 PHASE4 UNKNOWN

American Society of Anaesthesiologist physical status (ASA) I-III 105 patients who undergoing major abdominal surgery in obstetric and gynaecology clinic were recruited to this study. Patients were randomized into the 3 groups. Lumbar epidural catheter will be inserted to the all patients. After than anaesthesia induction will provide with 2 mg/kg propofol and 0.6 mg/kg rocuronium. Desflurane and azot protoxit (N2O)-O2 will use for anaesthesia maintenance. During surgical operation, 0.3 microgram/kg/h remifentanil infusion will continuous till the end of surgery. In group I, 2 ml serum physiologic (0.9 NaCL)will apply from epidural catheter before surgical incision. In group II, 1 mg morphine will apply from epidural catheter before surgical incision. In group III, 1 mg morphine will apply from epidural catheter at the time point of peritoneum is closed. Epidural patient controlled analgesia will provide with bupivacaine for postoperative analgesia. Postoperative pain will be assessed with numerical pain scale. Postoperative analgesic requirement will be calculated. Hyperalgesia will detect with algometer and von Frey ligaments.

Details

Lead sponsor	Cukurova University
Phase	PHASE4
Status	UNKNOWN
Enrolment	105
Start date	Wed Jul 19 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sat Dec 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Hyperalgesia

Interventions

• Morphine
• Serum physiologic

Countries

Turkey (Türkiye)