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NCT03225339: DIADEM-1
Diabetes Intervention Accentuating Diet and Enhancing Metabolism
NA trial testing Low Energy Diet in Diabetes Mellitus, Type 2 in 209 participants. Completed in 9 December 2020.
19 February 2020
Quick facts
| Lead sponsor | Weill Cornell Medical College in Qatar |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 209 |
| Start date | 16 July 2017 |
| Primary completion | 19 February 2020 |
| Estimated completion | 9 December 2020 |
| Sites | 2 locations across Qatar |
Drugs / interventions tested
- Low Energy Diet
Conditions studied
- Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
Sponsor
Weill Cornell Medical College in Qatar
Who can join
Adults 18 to 50, any sex, with Diabetes Mellitus, Type 2. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Diabetes is one of the greatest challenges faced by healthcare services worldwide. It is associated with serious complications such as heart attacks, stroke, and peripheral artery disease as well as kidney disease, eye disease, and nerve dysfunction. Data from weight loss with bariatric surgery suggest that with the appropriate intervention, it should be possible to reverse diabetes and that the earlier the intervention occurs, the greater the chances of placing diabetes into remission. There is now a need to translate this knowledge into the medical care of younger patients with early diabetes who are overweight/obese. The aim of this study is to see if younger adult patients with overweight/obesity and type 2 diabetes who are participants in a programme incorporating a low energy diet and physical activity (lifestyle) will lower their weight, cardiovascular risk and improve their glycaemic control as compared to the usual care.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial.
Taheri S, Zaghloul H, Chagoury O, Elhadad S, et al · · 2020 · cited 263× · PMID 32445735 · DOI 10.1016/s2213-8587(20)30117-0 -
Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mel
Taheri S, Chagoury O, Zaghloul H, Elhadad S, et al · · 2018 · cited 12× · PMID 29784059 · DOI 10.1186/s13063-018-2660-1 -
Clinical and metabolic characteristics of the Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I) randomised clinical trial cohort.
Zaghloul H, Chagoury O, Elhadad S, Hayder Ahmed S, et al · · 2020 · cited 5× · PMID 33293319 · DOI 10.1136/bmjopen-2020-041386
Verify or expand the search:
- PubMed search for NCT03225339
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Low Energy Diet
Trials testing the same drug.
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Other recruiting trials for Diabetes Mellitus, Type 2
Currently open trials in the same condition.
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- NCT07532863 — A Real-world Study to Investigate Cardiovascular Risk Profile Among Newly Diagnosed Type 2 Diabetes Mellitus (T2DM) Part · recruiting
- NCT07336329 — Continuous Glucose Monitoring in Non-Insulin Treated Type 2 Diabetes: Continuous vs. Periodic Use · NA · recruiting
- NCT07242469 — A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006) · Phase 1 · recruiting
- NCT07444203 — Transformative Research in Diabetic Nephropathy 2.0 · recruiting
Other Weill Cornell Medical College in Qatar trials
Trials by the same sponsor.
- NCT07515807 — Qatar Cardiometabolic Retrospective Cohort-Analysis Using Artificial Intelligence · not yet recruiting
- NCT07521033 — Development and Assessment of a 360° Video-Based Virtual Reality Application to Enhance Medical Students' Preparation fo · NA · completed
- NCT07163000 — Earlier Diagnosis of Peripheral Neuropathy Using A Simple sCreening Tool (ACT) · active not recruiting
- NCT04573101 — EEG Responses to Arabic Music Scales · NA · completed
- NCT03349840 — Randomised Open Label Study of Insulin Degludec Versus Insulin Glargine U100 in Ramadan · Phase 4 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03225339 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Weill Cornell Medical College in Qatar
- Last refreshed: 8 April 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03225339.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing