NCT03220750: UNIHOPE

University Hospital Advanced Age Pregnant Cohort

Status unknown Last updated 18 July 2017

What this trial tests

trial in Advanced Maternal Age Pregnancy in 22,000 participants. Status unknown.

Timeline

28 March 2017

Primary endpoint
31 December 2020

31 December 2020

Quick facts

Lead sponsor	Peking University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	22,000
Start date	28 March 2017
Primary completion	31 December 2020
Estimated completion	31 December 2020
Sites	9 locations across China

Conditions studied

• Advanced Maternal Age Pregnancy — all drugs for Advanced Maternal Age Pregnancy →
• High Risk Pregnancy — all drugs for High Risk Pregnancy →
• Perinatal Death — all drugs for Perinatal Death →
• Maternal Death — all drugs for Maternal Death →

Sponsor

Peking University

Who can join

Adults 35 to 60, female only, with Advanced Maternal Age Pregnancy or High Risk Pregnancy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The University Hospital Advanced Age Pregnant (UNIHOPE) Cohort is the major part of the National Key Research and Development Program on Reproductive Health \& Major Birth Defects Control and Prevention Project, which is funded by the Ministry of Science and Technology of China. The Project is led by Prof. Zhao Yangyu, from the Department of Gynecology \& Obstetrics, Peking University Third Hospital, and the UNIHOPE cohort is led by Prof. Jian-meng Liu, the Co-PI of the Project.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.
   Yang J, Hou L, Wang J, Xiao L, et al · · 2022 · cited 46× · PMID 35387876 · DOI 10.1136/gutjnl-2021-326482
2. Association of maternal age with adverse pregnancy outcomes: A prospective multicenter cohort study in China.
   Zhou Y, Yin S, Sheng Q, Yang J, et al · · 2023 · cited 31× · PMID 38038697 · DOI 10.7189/jogh.13.04161
3. Neonatal hair profiling reveals a metabolic phenotype of monochorionic twins with selective intrauterine growth restriction and abnormal umbilical artery flow.
   Yang J, Wei Y, Qi H, Yin N, et al · · 2020 · cited 15× · PMID 32357834 · DOI 10.1186/s10020-020-00160-8
4. Association of Paternal Age Alone and Combined with Maternal Age with Perinatal Outcomes: A Prospective Multicenter Cohort Study in China.
   Yin S, Zhou Y, Zhao C, Yang J, et al · · 2024 · cited 7× · PMID 38190051 · DOI 10.1007/s44197-023-00175-4
5. Chorionicity-associated variation in metabolic phenotype of cord blood in twin.
   Liu X, Yang J, Ran R, Long F, et al · · 2023 · cited 2× · PMID 37443030 · DOI 10.1186/s12986-023-00744-1
6. Association of weekend delivery and perinatal outcomes following cesarean delivery: a retrospective analysis of a multicenter prospective cohort study in China.
   Yuan P, Yin S, Guo X, Yang J, et al · · 2026 · PMID 41692770 · DOI 10.1186/s12884-026-08759-1
7. Duration of Folic Acid Supplementation and Adverse Pregnancy Outcomes: A Prospective Multicenter Cohort Study in China.
   Zhang M, Yu H, Li H, Zhou Y, et al · · 2025 · PMID 41515197 · DOI 10.3390/nu18010081