NCT03218891

Cardiac Rehabilitation in Patients With Refractory Angina

Completed NA Last updated 11 February 2022

What this trial tests

NA trial testing Cardiac Rehabilitation in Refractory Angina in 72 participants. Completed in 1 February 2022.

Timeline

1 January 2016

Primary endpoint
28 July 2020

1 February 2022

Quick facts

Lead sponsor	Hospital Israelita Albert Einstein
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	72
Start date	1 January 2016
Primary completion	28 July 2020
Estimated completion	1 February 2022
Sites	1 location across Brazil

Drugs / interventions tested

• Cardiac Rehabilitation

Conditions studied

• Refractory Angina — all drugs for Refractory Angina →

Sponsor

Hospital Israelita Albert Einstein

Who can join

Adults 45 to 75, any sex, with Refractory Angina. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate the safety and feasibility of cardiovascular rehabilitation in Patients with refractory angina, evaluate the effect of cardiovascular rehabilitation in patients with angina Refractory, by maximal oxygen consumption (VO2max) and global myocardial ischemic load by Stress Echocardiography; To evaluate the presence of myocardial injury, caused by physical stress, through ultra-sensitive troponin after sessions of aerobic physical activity, evaluating the behavior during the training period; To evaluate the effect of rehabilitation on the modulation of sympathetic activity and inflammation, muscular blood flow and lipid metabolism; To evaluate of the effect of rehabilitation on ventricular function through Stress echocardiography; Detection of ischemic episodes and arrhythmias identified during the Rehabilitation sessions through external cardiac monitoring (telemetry); Evaluate the quality of life assessment through the SF-36 questionnaire, Canadian Cardiovascular Society, the number of symptomatic episodes of ischemia, daily sublingual nitrate intake.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Does Myocardial Injury Occur After an Acute Aerobic Exercise Session in Patients with Refractory Angina?
   Montenegro CGSP, Dourado LOC, Jordão CP, Vieira MLC, et al · · 2022 · cited 4× · PMID 36453766 · DOI 10.36660/abc.20210564
2. Cardiopulmonary exercise test in patients with refractory angina: functional and ischemic evaluation.
   de Assumpção CRA, do Prado DML, Jordão CP, Dourado LOC, et al · · 2022 · cited 4× · PMID 35134662 · DOI 10.1016/j.clinsp.2021.100003
3. Safety and Efficacy of Exercise-based Cardiac Rehabilitation in Patients with Refractory Angina.
   Dourado LOC, Jordão CP, Vieira MLC, Gowdak LHW, et al · · 2025 · PMID 41637323 · DOI 10.36660/abc.20250331
4. “Safety and Efficacy of Exercise-based cardiac rehabilitation in patients with refractory angina: a randomized, controlled trial”
   Dourado LOC, Jordão CP, Vieira MLC, Gowdak LHW, et al · · 2024 · DOI 10.1101/2024.08.08.24311708
5. In the Cardiac Rehabilitation Era, is There a "No-Option" Refractory Angina Patient?: A Case Report.
   Dourado LOC, Jordão CP, Assumpção CRA, Matos LDNJ. · · 2023 · PMID 37878880 · DOI 10.36660/abc.20230007
6. Refractory Angina Referral to Cardiovascular Rehabilitation: A Neglected Patient.
   Milani M, Milani JGPO, Cipriano Junior G. · · 2022 · PMID 36453767 · DOI 10.36660/abc.20220695