PET-MRI Imaging in Patients With Acute Neurovascular Syndrome

NCT03215563 COMPLETED

Ischaemic stroke is a major cause of death and disability worldwide. In patients with recent stroke, the 18F-fluoride positron emission tomography-computed tomography highlights high-risk culprit carotid plaque and is more discriminatory than 18F-fluorodeoxyglucose. Using hybrid positron emission tomography-magnetic resonance imaging investigators propose to build upon these findings by prospectively assessing 18F-fluoride uptake in a broad range of patients with acute transient ischaemic attack or ischaemic stroke. Investigators will specifically examine the association of 18F-fluoride uptake with multiparametric magnetic resonance imaging assessments of atherosclerotic plaque, especially the role of thrombus and lipid. Finally, using transcranial Doppler and diffusion-weighted magnetic resonance brain imaging, an assessment of the functional consequences of 18F-fluoride-positive atherosclerotic plaque will be performed. If successful, this technique has a number of valuable translational applications including the better selection of patients for carotid intervention.

Details

Lead sponsor	University of Edinburgh
Status	COMPLETED
Enrolment	80
Start date	Thu Oct 12 2017 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Fri Jan 10 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Stroke
• Carotid Stenosis

Interventions

• 18F PET-MRI
• Transcranial Doppler

Countries

United Kingdom