Impact of Adjuvant Chemotherapy in Cardiovascular Autonomic Regulation in Patients With Colon Cancer

NCT03213444 NA COMPLETED

The present study aims to investigate the impact of adjuvant chemotherapy with 5-FU isolated and associated with oxaliplatin in cardiac autonomic control and endothelium-dependent vascular function in patients undergoing colectomy for stages II and III colon cancer. Will be performed evaluation of cardiac and vascular function, autonomic control, functional capacity and blood evaluations.

Details

Lead sponsor	University of Sao Paulo General Hospital
Phase	NA
Status	COMPLETED
Enrolment	30
Start date	2015-07
Completion	2019-02

Conditions

• Colon Cancer
• Adjuvant Chemotherapy

Interventions

• adjuvant chemotherapy with 5-FU isolated
• adjuvant chemotherapy with 5-FU associated with oxaliplatin

Primary outcomes

• cardiac function evaluation — Change from Baseline cardiac function at 6 months
  Cardiac function will be assessed by two-dimensional (B-mode) echocardiography, pulsed Doppler

Countries

Brazil