NCT03213184: CREW02

Children's Respiratory and Environmental Workgroup

Completed Last updated 14 August 2023

What this trial tests

trial in Asthma in 142 participants. Completed in 30 June 2023.

Timeline

26 December 2017

Primary endpoint
30 June 2023

30 June 2023

Quick facts

Lead sponsor	University of Wisconsin, Madison
Status	Completed
Study type	OBSERVATIONAL
Enrollment	142
Start date	26 December 2017
Primary completion	30 June 2023
Estimated completion	30 June 2023
Sites	10 locations across United States

Conditions studied

• Asthma — all drugs for Asthma →
• Allergic Asthma — all drugs for Allergic Asthma →
• Allergies — all drugs for Allergies →
• Healthy — all drugs for Healthy →

Sponsor

University of Wisconsin, Madison

Who can join

Eligibility, any sex, with Asthma or Allergic Asthma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The environment during the prenatal period and in early life is a major contributor to the risk of developing childhood asthma. Birth cohort studies from single research centers have identified several factors that affect the risk for developing childhood asthma, including being exposed in early life to allergens, pollutants, viruses and bacteria, and psychosocial stress. Despite such advances, further progress in understanding the root causes of asthma have been hampered by the small size of previous studies, which makes it difficult to: 1) identify asthma risk factors with certainty, 2) know how environmental factors across the United States (U.S.) affect asthma, and 3) whether there are critical ages when pregnant mothers, infants and young children are particularly susceptible to these influences. Furthermore, different research groups tend to use different methods to study asthma, making it difficult to either compare or pool findings. One other challenge is that there are several types (i.e. phenotypes, endotypes) of childhood asthma, but these are poorly understood. To help overcome these challenges, investigators leading 12 asthma birth cohorts across the U.S. have established the Children's Respiratory Research Workgroup (CREW) consortium. CREW proposes to identify specific types of childhood asthma, develop an understanding of what early life environmental influences cause these different types of asthma and when, and identify targets for future efforts aimed at preventing childhood asthma.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.