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NCT03210350
Effect of Magnesium Sulphate on the Intracranial Pressure of Preeclamptic Patients
trial testing Optic nerve sheath diameter in Preeclampsia Severe in 30 participants. Completed in 30 September 2018.
30 July 2018
Quick facts
| Lead sponsor | Corniche Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 1 August 2017 |
| Primary completion | 30 July 2018 |
| Estimated completion | 30 September 2018 |
| Sites | 1 location across United Arab Emirates |
Drugs / interventions tested
- Optic nerve sheath diameter
Conditions studied
- Preeclampsia Severe — all drugs for Preeclampsia Severe →
Sponsor
Corniche Hospital
Who can join
Adults 18 to 40, female only, with Preeclampsia Severe. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
It had been shown that high percentage of severe preeclampsia patients got a high cerebral perfusion pressure (CPP) due to abnormal autoregulation of cerebral blood vessels with associated endothelial dysfunction and disrupted blood brain barrier. Moreover, patients with high CPP is more likely to present with headache compared to other patients with normal CPP.In this particular scenario, use of magnesium sulphate is associated with marked reduction of CPP and. hence prevention of cerebral damage.This hypothesis was confirmed by new magnetic resonance techniques that demonstrated brain edema in eclampsia/ severe preeclampsia patient mostly due to vasogenic edema and less commonly attributed to cytotoxic edema. Changes in the optic nerve sheath diameter (ONSD) mirrors the changes in the Intracranial pressure(ICP), subsequently when the intracranial pressure increases the optic nerve sheath diameter (ONDS) also increases. The aim of this study is to determine the effect Magnesium sulphate infusion on intracranial pressure, in patients presented with severe preeclampsia by measuring changes in the ONSD using ultrasound examination.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03210350
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Related trials
Other trials of Optic nerve sheath diameter
Trials testing the same drug.
- NCT04428229 — Optic Nerve Sheath Diameter in Laparoscopic Surgeries During Trendelenburg Position · completed
- NCT04370847 — Ultrasonography for Fluid Assessment in Parturients With Preeclampsia Undergoing Cesarean Section · completed
- NCT03795896 — Ocular Ultrasonography as a Tool for Monitoring the Management of Traumatic Brain Injury · NA · unknown
Other recruiting trials for Preeclampsia Severe
Currently open trials in the same condition.
- NCT06373367 — Preeclampsia Educational Program Study (PrEPS) · NA · active not recruiting
- NCT06360601 — Intravenous Labetalol Versus Hydralazine in Preeclampsia · Phase 1, PHASE2 · recruiting
- NCT07361679 — LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention · Phase 4 · recruiting
Other Corniche Hospital trials
Trials by the same sponsor.
- NCT03516786 — Quality of Recovery After Quadratus Lumborum Block for Cesarean Section. · completed
- NCT02718924 — Detecting Hypercoagulability in Morbidly Obese and Non Obese Parturients Following Cesarean Section Delivery · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03210350 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Corniche Hospital
- Last refreshed: 31 May 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03210350.
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