NCT03209674 (RIPOSTE) is a clinical trial of Cardiothoracic surgery in Heart Diseases, sponsored by CMC Ambroise Paré.

Who is sponsoring NCT03209674?

NCT03209674 is sponsored by CMC Ambroise Paré.

What drugs are being tested in NCT03209674?

Interventions in NCT03209674: Cardiothoracic surgery.

What condition does NCT03209674 study?

NCT03209674 studies Heart Diseases, Death, Postoperative Complications, Cardiac Complication.

Is NCT03209674 still recruiting?

NCT03209674 is currently recruiting now. Last updated 3 April 2026.

Last reviewed 2026-04-03 · How we verify

NCT03209674: RIPOSTE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry

Recruiting now Last updated 3 April 2026

What this trial tests

trial testing Cardiothoracic surgery in Heart Diseases in 8,000 participants. Currently enrolling.

Timeline

1 January 2012

Primary endpoint
31 December 2030

31 December 2030

Quick facts

Lead sponsor	CMC Ambroise Paré
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	8,000
Start date	1 January 2012
Primary completion	31 December 2030
Estimated completion	31 December 2030
Sites	1 location across France

Drugs / interventions tested

Cardiothoracic surgery

Conditions studied

Heart Diseases — all drugs for Heart Diseases →
Death — all drugs for Death →
Postoperative Complications — all drugs for Postoperative Complications →
Cardiac Complication — all drugs for Cardiac Complication →

Sponsor

CMC Ambroise Paré — full company profile →

Who can join

Eligibility, any sex, with Heart Diseases or Death. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The registry for the improvement of postoperative outcomes in cardiac and thoracic surgery aims to prospectively collect data in order to test the association between various preoperative and per-operative variables ; and several postoperative outcomes such as mortality, shock, redo surgery, sepsis and extracorporeal life-support.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Post-operative Right Ventricular Failure After Cardiac Surgery: A Cohort Study.
Levy D, Laghlam D, Estagnasie P, Brusset A, et al · · 2021 · cited 35× · PMID 34195233 · DOI 10.3389/fcvm.2021.667328
Takotsubo cardiomyopathy after cardiac surgery: A case-series and systematic review of literature.
Laghlam D, Touboul O, Herry M, Estagnasié P, et al · · 2022 · cited 7× · PMID 36704455 · DOI 10.3389/fcvm.2022.1067444
Effect of BNP on risk assessment in cardiac surgery patients, in addition to EuroScore II.
Suc G, Estagnasie P, Brusset A, Procopi N, et al · · 2020 · cited 6× · PMID 32616802 · DOI 10.1038/s41598-020-67607-0
Risk factors and complications associated with intra-operative or post-operative identification of a PFO in cardiac surgery patients: A cohort study.
Laghlam D, Coroyer L, Martial PJ, Estagnasie P, et al · · 2022 · PMID 36703625 · DOI 10.3389/fneur.2022.1057479
Incidence and prognosis associated with troponin elevation after cardiac surgery: a prospective cohort study
Clément A, Daulasim A, Souibri M, Nguyen L. · · 2022

Verify or expand the search:

Other trials of Cardiothoracic surgery

Trials testing the same drug.

NCT04866147 — Prediction of Chronic Postsurgical Pain in Adults · completed

Other recruiting trials for Heart Diseases

Currently open trials in the same condition.

NCT07288216 — Transition to KPL-387 Monotherapy Dosing & Administration Study · Phase 2 · recruiting
NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
NCT07286578 — A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Under · NA · recruiting
NCT06954610 — Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation · recruiting
NCT06769880 — Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Fa · NA · recruiting

Other CMC Ambroise Paré trials

Trials by the same sponsor.

NCT07477730 — Local Infiltration Analgesia Versus Quadruple Nerve Blocks in Total Knee Arthroplasty. · NA · not yet recruiting
NCT07345559 — Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock · NA · recruiting
NCT07332949 — Impact of Dialysis on Sexuality. · recruiting
NCT06777355 — Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Sur · completed
NCT06327334 — Brain Heart InterActioNs in Cardiac Arrest. Ancillary Study of the HEAVENwARd Trial · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03209674 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by CMC Ambroise Paré
Last refreshed: 3 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03209674.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing