Last reviewed · How we verify

NCT03208985: LIBRella

A Study of Use of Ella®, an Emergency Contraceptive, Under Simulated OTC Conditions

Completed Phase 3 Results posted Last updated 2 December 2022
What this trial tests

Phase 3 trial testing Use Phase (Ulipristal Acetate, 30 mg) in Emergency Contraception in 1,270 participants. Completed in 14 June 2018.

Timeline
23 May 2017
Primary endpoint
14 June 2018
14 June 2018

Quick facts

Lead sponsorHRA Pharma
PhasePhase 3
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposeother
Enrollment1,270
Start date23 May 2017
Primary completion14 June 2018
Estimated completion14 June 2018
Sites34 locations across United States

Drugs / interventions tested

Conditions studied

Sponsor

HRA Pharma — full company profile →

Who can join

Eligibility, female only, with Emergency Contraception. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Proportion of Dosing Instances Among User Population Taken Within 120 Hours (5 Days) of Most Recent Episode of Unprotected Sex. Primary · Up to 6 Weeks

The first primary endpoint is the proportion in which the denominator includes all dosing instances of the IP and the numerator includes all dosing instances of the IP which were taken within 120 hours (5 days) of the subject's most recent episode of unprotected sex.

GroupValue95% CI
Use Phase (Ulipristal Acetate, 30 mg)704
Proportion of Dosing Instances Among User Population in Which no More Than One Tablet Was Taken. Primary · Up to 6 Weeks

The second primary endpoint is the proportion in which the denominator is all discrete dosing instances of the IP and the numerator includes all dosing instances where no more than one tablet was taken.

GroupValue95% CI
Use Phase (Ulipristal Acetate, 30 mg)712
Proportion of Female Selectors Who Are Not Pregnant at the Time of Selection Decision. Primary · Day 1

The third primary endpoint is the proportion in which the denominator includes all females who selected to use the product (regardless of whether they purchased/used) and the numerator includes all female selectors who were not pregnant at the time of the selection decision.

GroupValue95% CI
Self-Selection Population814

Adverse events — posted to ClinicalTrials.gov

Time frame: up to 6 weeks. Reporting threshold: 0.1%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Safety Population
Serious: 15/783 (2%)
Deaths: 0/783

Serious adverse events (6 terms)

ReactionSystemSafety Population
Exposure During PregnancyPregnancy, puerperium and perinatal conditions
Spontaneous abortionsPregnancy, puerperium and perinatal conditions
Volvulus of bowelGastrointestinal disorders
Kidney infectionRenal and urinary disorders
Allergic reactionImmune system disorders
PneumoniaRespiratory, thoracic and mediastinal disorders
Other adverse events (29 terms — click to expand)

ReactionSystemSafety Population
Abdominal pain lowerGastrointestinal disorders
NauseaGastrointestinal disorders
FatigueGeneral disorders
Urinary tract infectionRenal and urinary disorders
Viral upper respiratory tract infectionRespiratory, thoracic and mediastinal disorders
Abdominal painGastrointestinal disorders
HeadacheGeneral disorders
InfluenzaImmune system disorders
Bacterial vaginosisInfections and infestations
Decreased appetiteGastrointestinal disorders
RashImmune system disorders
Vaginal infectionRenal and urinary disorders
Breast tendernessReproductive system and breast disorders
DysmenorrhoeaReproductive system and breast disorders
Exposure during breast feedingInjury, poisoning and procedural complications
LacerationPsychiatric disorders
Vaginal haemorrhageReproductive system and breast disorders
Abortion spontaneousPregnancy, puerperium and perinatal conditions
Back painMusculoskeletal and connective tissue disorders
BronchitisInfections and infestations
DiarrhoeaGastrointestinal disorders
DizzinessEar and labyrinth disorders
SinusitisInfections and infestations
Tooth infectionInfections and infestations
TrichomoniasisPsychiatric disorders
UrticariaImmune system disorders
VomitingMetabolism and nutrition disorders
Vulvovaginal mycotic infectionReproductive system and breast disorders
HypersensitivityImmune system disorders

Most-reported serious reactions: Exposure During Pregnancy, Spontaneous abortions, Volvulus of bowel, Kidney infection, Allergic reaction, Pneumonia.

Data from ClinicalTrials.gov NCT03208985 adverse events section.

Sponsor's own description

This study is designed to assess whether consumers select and use ella® (ulipristal acetate 30mg), an emergency contraceptive, in a manner consistent with the OTC package directions in an OTC-like setting.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Emergency Contraception

Currently open trials in the same condition.

Other HRA Pharma trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03208985.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing