NCT03200639

Cachexia in Gynecological Cancer and the Preventive Role of Weight Training

Completed NA Last updated 27 June 2017

What this trial tests

NA trial testing Combined training in Breast Cancer Female in 38 participants. Completed in 10 December 2015.

Timeline

30 May 2015

Primary endpoint
1 December 2015

10 December 2015

Quick facts

Lead sponsor	Universidade Federal do Triangulo Mineiro
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	38
Start date	30 May 2015
Primary completion	1 December 2015
Estimated completion	10 December 2015

Drugs / interventions tested

• Combined training
• High intensity interval training with body weight

Conditions studied

• Breast Cancer Female — all drugs for Breast Cancer Female →
• Gynecologic Cancer — all drugs for Gynecologic Cancer →
• Menopause — all drugs for Menopause →
• Physical Activity — all drugs for Physical Activity →

Sponsor

Universidade Federal do Triangulo Mineiro

Who can join

50 and older, female only, with Breast Cancer Female or Gynecologic Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study aim was to compare the effectiveness of combined training (CT; aerobic + resistance exercises) and high-intensity interval body weight training (HIITBW) on body composition, metabolic and inflammatory profile, physical function and quality of life in older women with gynecological and breast cancer and their pair-matched controls (older women with no cancer). The hypothesis of the present clinical trial is that HIITBW is effective as well as CT for improvements on body composition, metabolic and inflammatory profile, physical function and quality of life in older women with gynecological and breast cancer.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. High-intensity body weight training is comparable to combined training in changes in muscle mass, physical performance, inflammatory markers and metabolic health in postmenopausal women at high risk for type 2 diabetes mellitus: A randomized controlled clinical trial.
   Martins FM, de Paula Souza A, Nunes PRP, Michelin MA, et al · · 2018 · cited 33× · PMID 29471132 · DOI 10.1016/j.exger.2018.02.016
2. Comparative effects of high-intensity interval training with combined training on physical function markers in obese postmenopausal women: a randomized controlled trial.
   Nunes PRP, Martins FM, Souza AP, Carneiro MAS, et al · · 2019 · cited 14× · PMID 31479035 · DOI 10.1097/gme.0000000000001399
3. Functional high-intensity interval training is not equivalent when compared to combined training for blood pressure improvements in postmenopausal women: a randomized controlled trial.
   Nunes PRP, Silva TRGB, Carneiro MAS, Martins FM, et al · · 2022 · cited 5× · PMID 34749549 · DOI 10.1080/10641963.2021.2001481
4. Body Mass Index, waist circumference or sagittal abdominal diameter: Which parameter is better correlated with body fat changes in postmenopausal women after combined training protocol?
   Limirio LS, Rossato LT, Barbosa CD, Teixeira KRC, et al · · 2020 · cited 1× · PMID 32690157 · DOI 10.1016/j.clnesp.2020.05.004