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NCT03199131: MVD
The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging
NA trial testing Right ventricular biopsies in Chronic Thromboembolic Pulmonary Hypertension in 20 participants. Completed in 20 October 2018.
20 November 2017
Quick facts
| Lead sponsor | Centre Chirurgical Marie Lannelongue |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 20 |
| Start date | 20 February 2017 |
| Primary completion | 20 November 2017 |
| Estimated completion | 20 October 2018 |
| Sites | 1 location across France |
Drugs / interventions tested
- Right ventricular biopsies
Conditions studied
- Chronic Thromboembolic Pulmonary Hypertension — all drugs for Chronic Thromboembolic Pulmonary Hypertension →
Sponsor
Centre Chirurgical Marie Lannelongue — full company profile →
Who can join
18 and older, any sex, with Chronic Thromboembolic Pulmonary Hypertension. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronically elevated pulmonary pressures do not immediately result in right ventricular failure. During the initial period of exposure, the RV adapts to the increased afterload by altering its metabolism and morphology so as to meet the increased work requirement. Several, interconnected adaptive mechanisms have been proposed, including myocyte hypertrophy, a switch in the primary fuel used for ATP generation, increased angiogenesis, and decreased production of mitochondrial reactive oxygen species. While adaptation is initially successful in many cases, it is temporary, and after an uncertain period of time, the ventricle begins to fail. This transition from a compensated to decompensated state is difficult to predict clinically, and patients with different etiologies of CPOS progress to overt RV failure over significantly different time periods. This variability hinders the implementation of treatments that are tailored to a specific disease stage.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03199131
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Thromboembolic Pulmonary Hypertension
Currently open trials in the same condition.
- NCT07272798 — Cardiac Self-Efficacy in Patients With Chronic Thromboembolic Pulmonary Hypertension · recruiting
- NCT07254078 — Registry of Patients With chrOnic thromboemboLic Pulmonary hypErTension · recruiting
- NCT06922240 — Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART) · Phase 3 · recruiting
- NCT06081881 — Chronic Thromboembolic Pulmonary Hypertension After Pulmonary Embolism · recruiting
- NCT06715280 — Switching of Sildenafil to Riociguat in CTEPH Patients · Phase 4 · recruiting
Other Centre Chirurgical Marie Lannelongue trials
Trials by the same sponsor.
- NCT05865119 — OPTImal Treatment of Sinus VENOSUS Defect · NA · recruiting
- NCT05692310 — Study of the Effectiveness of Central Line Placement Using an Ultraportable Ultrasound Device · NA · unknown
- NCT05717296 — Evaluation of the Effectiveness of a Multimedia Information Site in Reducing Preoperative Anxiety in Vascular Surgery Pa · NA · unknown
- NCT06186258 — Infective Endocarditis in Percutaneous Pulmonary Revalvulation: Comparison Between Melody and Sapien Valves · completed
- NCT05125965 — Contribution of Cardiac MRI in the Early Diagnosis of Myocarditis Induced by Immunotherapy · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03199131 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Chirurgical Marie Lannelongue
- Last refreshed: 23 January 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03199131.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing