Last reviewed · How we verify
NCT03198208
Intraoperative Fentanyl Dose on Respiratory Complications
trial testing Fentanyl dose administration in Fentanyl in 183,396 participants. Status unknown.
31 December 2015
Quick facts
| Lead sponsor | Massachusetts General Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 183,396 |
| Start date | 1 January 2007 |
| Primary completion | 31 December 2015 |
| Estimated completion | 30 June 2018 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Fentanyl dose administration — full drug profile →
Conditions studied
- Fentanyl — all drugs for Fentanyl →
- Opioid Use — all drugs for Opioid Use →
- Surgery — all drugs for Surgery →
- Respiratory Complication — all drugs for Respiratory Complication →
Sponsor
Massachusetts General Hospital
Who can join
18 and older, any sex, with Fentanyl or Opioid Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Fentanyl is the most commonly used opioid during anesthesia at Massachusetts General Hospital. Compared to other opioids, e.g. sulfentanil and remifentanil, fentanyl's pharmacokinetic properties are more problematic as the context sensitive half-time increases with duration of fentanyl infusion. This may lead to respiratory complications particularly in patients who receive fentanyl for surgical procedures of long duration. Considering the common use of fentanyl during surgery and its duration of action that is hard to predict during long surgical procedures, we will evaluate the association between intraoperative fentanyl dose and postoperative respiratory complications within 3 days of surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of low-dose intraoperative fentanyl on postoperative respiratory complication rate: a pre-specified, retrospective analysis.
Friedrich S, Raub D, Teja BJ, Neves SE, et al · · 2019 · cited 27× · PMID 30982564 · DOI 10.1016/j.bja.2019.03.017
Verify or expand the search:
- PubMed search for NCT03198208
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Fentanyl
Currently open trials in the same condition.
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- NCT06386783 — Fentanyl Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Spinal Anesthesia ; Peritoneal Symptomatic Effects · Phase 3 · recruiting
Other Massachusetts General Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03198208 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Massachusetts General Hospital
- Last refreshed: 26 June 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03198208.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing