Who is sponsoring NCT03197454?

NCT03197454 is sponsored by Posit Science Corporation.

What drugs are being tested in NCT03197454?

Interventions in NCT03197454: Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training.

What condition does NCT03197454 study?

NCT03197454 studies Age-related Cognitive Decline.

Is NCT03197454 still recruiting?

NCT03197454 is currently completed. Last updated 31 October 2023.

Last reviewed 2023-10-31 · How we verify

NCT03197454: BETTER Aging

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Brain Enhancement Training Towards Elders Resilience to Aging

Completed NA Last updated 31 October 2023

What this trial tests

NA trial testing Computerized Plasticity-Based Adaptive Cognitive Training in Age-related Cognitive Decline in 147 participants. Completed in 16 July 2021.

Timeline

1 June 2018

Primary endpoint
16 July 2021

16 July 2021

Quick facts

Lead sponsor	Posit Science Corporation
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	147
Start date	1 June 2018
Primary completion	16 July 2021
Estimated completion	16 July 2021
Sites	2 locations across United States

Drugs / interventions tested

Computerized Plasticity-Based Adaptive Cognitive Training
Commercially available computerized training

Conditions studied

Age-related Cognitive Decline — all drugs for Age-related Cognitive Decline →

Sponsor

Posit Science Corporation — full company profile →

Who can join

65 and older, any sex, with Age-related Cognitive Decline. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is a parallel arm, double-blind, randomized, controlled clinical trial to assess the efficacy of an experimental software program designed to improve cognitive functions versus a computer-based software control. Both the study and the software being investigated meet the criteria of Non-Significant Risk.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The Effects of Computerized Cognitive Training in Older Adults' Cognitive Performance and Biomarkers of Structural Brain Aging.
Lee HK, Basak C, Grant SJ, Ray NR, et al · · 2024 · cited 6× · PMID 38686621 · DOI 10.1093/geronb/gbae075
Brain activations elicited during task-switching generalize beyond the task: A partial least squares correlation approach to combine fMRI signals and cognition.
Skolasinska P, Qin S, Voss M, Lee HK, et al · · 2024 · cited 3× · PMID 39126346 · DOI 10.1002/hbm.26804

Verify or expand the search:

Other trials of Computerized Plasticity-Based Adaptive Cognitive Training

Trials testing the same drug.

NCT06589024 — Remote STATE Training for Insomnia in Older Adults · NA · active not recruiting
NCT05599490 — Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB · NA · completed
NCT05022589 — Remote Digital Health Intervention to Improve Balance and Reduce Fall Risk · NA · completed
NCT04149457 — Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise · NA · completed
NCT03604380 — STATE Trial: SusTained Attention Training to Enhance Sleep - Remote · NA · completed

Other recruiting trials for Age-related Cognitive Decline

Currently open trials in the same condition.

NCT06948136 — Acute Effects of THC in Older Adult · Phase 1 · recruiting
NCT06964399 — The Effect of Reminiscence Therapy in Elderly · NA · recruiting
NCT06893432 — Cognitive Function and EEG Brain Network Remodeling Among Users of Hearing Aids With ARHL · active not recruiting
NCT06377254 — Multi-organ Responses to CHronic Physical Activity and INactivity · NA · recruiting
NCT04184375 — Cognitive Stimulation for Elderly Bipolar Patients · NA · recruiting

Other Posit Science Corporation trials

Trials by the same sponsor.

NCT07243600 — Improving Neurological Health With Acetylcholine Via Neuroplasticity-based Computerized Exercise in Mild Cognitive Impai · NA · not yet recruiting
NCT06589024 — Remote STATE Training for Insomnia in Older Adults · NA · active not recruiting
NCT05599490 — Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB · NA · completed
NCT05529706 — Community-based Brain Health Program to Address Dementia Risk · NA · completed
NCT05022589 — Remote Digital Health Intervention to Improve Balance and Reduce Fall Risk · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03197454 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Posit Science Corporation
Last refreshed: 31 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03197454.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing