Exercise Training and Cognitive Function in Kidney Disease
CompletedNAResults postedLast updated 2 July 2021
What this trial tests
NA trial testing Partially supervised home-based walking exercise in Cognitive Function, Preclinical in 39 participants. Completed in 18 December 2019.
Adults 60 to 80, any sex, with Cognitive Function, Preclinical or Chronic Kidney Diseases. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Composite Global Cognitive FunctionPrimary· Change from baseline in composite global cognitive function at 6 months
Determine the effect of a 6-month home-based exercise program on composite global cognitive functioning as determined by principal component analysis of immediate free recall of trials 1-5 on California verbal learning II, long-delay free recall and recognition, and memory discriminability, trail making test part A and part B, digit symbol substitution test, semantic and phonemic fluency, and Digit span subtest in older patients with kidney disease and preclinical cognitive impairment. A composite global cognitive score was created by converting the individual cognitive scores to standardized
Group
Value
95% CI
Home-based Walking Exercise
.15
± .37
Control
.02
± .33
Composite Executive FunctionPrimary· Change from baseline in composite executive function at 6 months
A composite executive functioning score was created by converting 4 individual executive cognitive scores (verbal fluency FAS and animal summary score, digit span backward subtest, and TMT-B) to standardized z scores and then averaging the standardized z scores. A larger change in Z score is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
0.21
± .47
Control
-.01
± .47
White Matter IntegritySecondary· Change from baseline white matter integrity fractional anisotropy at 6 months
Whole brain white matter integrity was created by averaging the fractional anisotropy of 80 tracts using region of interest analysis. An increased change from baseline to 6 months in fractional anisotropy (a measure of directionality, 0 = no principle direction, 1 = one principle direction) is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
-.002
± .02
Control
.003
± .01
Hippocampal Volume - RightSecondary· Change from baseline hippocampal volume at 6 months.
Determine the effect of a 6-month exercise program on hippocampal volume. An increased change from baseline to 6 months in right hippocampal volume in cubic millimeters is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
.003
± .0002
Control
.003
± .003
Cerebral Blood FlowSecondary· Change from baseline in cerebral blood flow at 6 months.
Determine the effect of a 6-month exercise program on cerebral blood flow. Change in global cerebral blood measured in mL/100g/min from baseline to 6 months. An larger change is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
1.6
± 9.8
Control
0.3
± 12.2
Vascular Health - Young's Elastic ModulusSecondary· Change from baseline in vascular health indices at 6 months
Vascular health was assessed by Young's Elastic Modulus (YEM) at the carotid artery. A larger negative change in YEM (measured in kilo pascal, stiffer artery=higher number) from baseline to 6 months is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
-3,175
± 9,428
Control
1,279
± 8,654
Cognitive Function - Total CognitionSecondary· Mean change from baseline to 6 months.
Determine the effect of a 6-month exercise program on cognitive function via the NIH toolbox
This composite includes: Flanker, Dimensional Change Card Sort, Picture Sequence Memory, List Sorting and Pattern Comparison. This composite score is derived by averaging the standard scores of each of the measures, and then deriving standard scores based on this new distribution. An Age-Corrected Standard Score was used.
Scale runs 140 to 23, a higher score means a better outcome. An increased change from baseline to 6 months is considered an improvement
Group
Value
95% CI
Home-based Walking Exercise
8
± 7.4
Control
11
± 7.6
Motor Function - Grip StrengthSecondary· Change from baseline in NIH toolbox motor function indices at 6 months
Determine the effect of a 6-month exercise program on motor function via the NIH toolbox. Age corrected grip strength on a standard scale. Standard scale 140-23, higher score is better. An increased change from baseline to 6 months is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
3
± 6.2
Control
-2.5
± 7.2
Vascular Health - Pulse Wave VelocitySecondary· 6 Months
Vascular function indices of vascular health was assessed using pulse wave velocity of the aorta in meters/second (higher number =more stiff aorta). A larger negative change from baseline to 6 months is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
-.01
± 1.1
Control
.21
± .92
Vascular Health - Augmentation IndexSecondary· 6 Months
Vascular function indices of vascular health was assessed using augmentation index at the carotid artery (in percentage, higher percent=more stiff artery). A larger negative change from baseline to 6 months is considered an improvement.
Group
Value
95% CI
Home-based Walking Exercise
-2.6
± 12.1
Control
3.3
± 16.6
Cognitive Function - Fluid CognitionSecondary· Mean change from baseline to 6 months.
Determine the effect of a 6-month exercise program on cognitive function via the NIH toolbox. Fluid cognition.
This composite includes: Flanker, Dimensional Change Card Sort, Picture Sequence Memory, List Sorting and Pattern Comparison. This composite score is derived by averaging the standard scores of each of the measures, and then deriving standard scores based on this new distribution. An Age-Corrected Standard Score was used. A larger change from baseline to 6 months is considered an improvement.
Scale runs 140 to 23, a higher score means a better outcome.
Group
Value
95% CI
Home-based Walking Exercise
5.2
± 12.2
Control
11
± 8.9
Cognitive Function - Crystalized CognitionSecondary· Mean change from baseline to 6 months.
Change from baseline in NIH toolbox cognitive function indices at 6 months. Crystalized cognition.
This composite includes : Flanker, Dimensional Change Card Sort, Picture Sequence Memory, List Sorting and Pattern Comparison. This composite score is derived by averaging the standard scores of each of the measures, and then deriving standard scores based on this new distribution. An Age-Corrected Standard Score was used.
An larger change from baseline to 6 months is considered an improvement. Scale runs 140 to 23, a higher score means a better outcome.
Group
Value
95% CI
Home-based Walking Exercise
7.7
± 7.5
Control
8.3
± 7.1
Adverse events — posted to ClinicalTrials.gov
Time frame: 6 months..
Reporting threshold: 0%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
Chronic kidney disease (CKD), affects over 45% of all individuals over 70 years of age. Patients with moderate CKD have more than a two-fold increased risk of cognitive impairment than those without CKD; furthermore, as many as 20-70% of patients with CKD have established cognitive impairment and overt dementia. The burden of cognitive impairment and dementia leads to functional decline and accelerated loss of independence, contributing to the tremendous individual, societal, and economic burden of CKD (i.e., 20% of Medicare expenditures in adults \>65 years of age). There is no recommended treatment to prevent cognitive decline in CKD patients, and the few medications available for cognitive impairment have only short term modest effects. There is a critical need to evaluate therapies to forestall cognitive impairment, and maintain or improve cognitive functioning in older patients with CKD. To address this need, this study will test the hypothesis that older patients with moderate/severe CKD and pre-clinical cognitive impairment randomized to a 6-month home-based exercise program will improve cognitive function and MRI measured brain structure, compared to a usual care control group. This study will combine an assessment of cognition with MR imaging techniques to fully evaluate brain structure, blood flow, and behavior relationships at a level previously not conducted in this population
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Illinois at Chicago
Last refreshed: 2 July 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03197038.