NCT03191409

Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease

Status unknown Last updated 14 July 2017

What this trial tests

trial in End-stage Kidney Disease in 50 participants. Status unknown.

Timeline

15 June 2017

Primary endpoint
15 June 2019

30 June 2019

Quick facts

Lead sponsor	First Affiliated Hospital Xi'an Jiaotong University
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	50
Start date	15 June 2017
Primary completion	15 June 2019
Estimated completion	30 June 2019
Sites	2 locations across China

Conditions studied

• End-stage Kidney Disease — all drugs for End-stage Kidney Disease →
• Brain Damage — all drugs for Brain Damage →

Sponsor

First Affiliated Hospital Xi'an Jiaotong University

Who can join

Adults 18 to 50, any sex, with End-stage Kidney Disease or Brain Damage. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

End stage renal disease (ESRD) is the last stage (stage 5) of chronic kidney disease (CKD). Abnormalities of cognitive function and high levels of depression or anxiety incidence are characteristic of hemodialysis patients. In this research project, the investigators subject in ESRD patients starting hemodialysis as the carrier. Based on the longitudinal research design, using multimodal neuroimaging data，combining with the interact relationship between changes of brain morphology, the dysfunction of resting-state and-task state with cognitive impairment and abnormal emotions.Establish brain structure-function change model associated with dialysis progression, Explore imaging markers of central and disease development characteristics in ESRD patients. the investigators attempt to clarify the core mechanism of kidney-brain axis damage, thus provide evidence for early cognitive-behavioral therapy to CKD patient.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Reversal of neurovascular decoupling and cognitive impairment in patients with end-stage renal disease during a hemodialysis session: Evidence from a comprehensive fMRI analysis.
   Li P, Ma S, Ma X, Ding D, et al · · 2023 · cited 17× · PMID 36269166 · DOI 10.1002/hbm.26122
2. Brain connectome gradient dysfunction in patients with end-stage renal disease and its association with clinical phenotype and cognitive deficits.
   Li P, Li N, Ren L, Yang YP, et al · · 2025 · cited 2× · PMID 40325140 · DOI 10.1038/s42003-025-08132-6
3. Salt-sensitive hypertension promotes neuronal mitochondrial stress and neurodegenerative alterations via neuro-vascular metabolic reprogramming and local RAS signaling.
   Wu H, Qiu Z, Mu J, Wang Y, et al · · 2025 · cited 1× · PMID 41039568 · DOI 10.1186/s12974-025-03533-0