NCT03189407

Effect of Moringa Oleifera on Metformin Plasma Level in Type 2 Diabetes Mellitus Patients

Completed NA Last updated 16 June 2017

What this trial tests

NA trial testing Moringa oleifera tea in Type 2 Diabetes Mellitus in 25 participants. Completed in 30 April 2016.

Timeline

1 March 2016

Primary endpoint
30 April 2016

30 April 2016

Quick facts

Lead sponsor	Titilayo O Fakeye
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	25
Start date	1 March 2016
Primary completion	30 April 2016
Estimated completion	30 April 2016

Drugs / interventions tested

• Moringa oleifera tea

Conditions studied

• Type 2 Diabetes Mellitus — all drugs for Type 2 Diabetes Mellitus →

Sponsor

Titilayo O Fakeye

Who can join

Adults 49 to 77, any sex, with Type 2 Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Type 2 diabetes mellitus (T2DM) patients from our previous survey tend to co-administer various herbs with their oral hypoglycemic agents (OHA). Some of these herbs are known to possess antidiabetic activities. One of such is Moringa oleifera leaves.

The present study evaluated the effects of seven days, twice-daily administration of hot water infusion of dried Moringa oleifera leaves on the steady state plasma concentrations of Metformin, one of the most widely used OHAs using T2DM patients who have been on Metformin for a period of not less than three months. The included patients had also been on Moringa supplementation but had terminated the use of Moringa at least a month to the start of the study.

Patients who had other comorbidities such as heart diseases, renal or hepatic impairments were excluded from the study. The patients were recruited from Endocriniology clinic of the Obafemi Awolowo University Teaching Hospitals complex, a tertiary hospital from southwest Nigeria.

Each patient served as his/her control.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Effects of <i>Moringa oleifera</i> on Glycaemia and Insulin Levels: A Review of Animal and Human Studies.
   Vargas-Sánchez K, Garay-Jaramillo E, González-Reyes RE. · · 2019 · cited 27× · PMID 31810205 · DOI 10.3390/nu11122907
2. The "Colors" of Moringa: Biotechnological Approaches.
   Villegas-Vazquez EY, Padilla-Mendoza JR, Carrillo-Pérez MS, Gómez-Cansino R, et al · · 2025 · PMID 40805688 · DOI 10.3390/plants14152338