NCT03188757

The Influence of Acute Hyperglycaemia on Brain in T1D

Completed NA Last updated 9 May 2018

What this trial tests

NA trial testing hyperglycaemic clamp in Hyperglycemia in 20 participants. Completed in 30 March 2018.

Timeline

13 July 2017

Primary endpoint
30 March 2018

30 March 2018

Quick facts

Lead sponsor	University of Ljubljana, Faculty of Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	20
Start date	13 July 2017
Primary completion	30 March 2018
Estimated completion	30 March 2018
Sites	1 location across Slovenia

Drugs / interventions tested

• hyperglycaemic clamp

Conditions studied

• Hyperglycemia — all drugs for Hyperglycemia →
• Type 1 Diabetes Mellitus — all drugs for Type 1 Diabetes Mellitus →

Sponsor

University of Ljubljana, Faculty of Medicine

Who can join

Adults 12 to 20, any sex, with Hyperglycemia or Type 1 Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study is going to include 20 adolescents, 5-10 years after onset of T1D, aged 12-20 years, on insulin pump. The participants are going to have MRI of the head in euglycaemic and hyperglycaemic state. During both MRI, the participants are going to preform Flanker test, Tower of London test and Spatial memory test. The investigators are going to evaluate the response of inflammation markers and oxidative stress marekers in blood during hypreglycaemia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes.
   Šuput Omladič J, Slana Ozimič A, Vovk A, Šuput D, et al · · 2020 · cited 42× · PMID 32471909 · DOI 10.2337/dc20-0171