Last reviewed · How we verify
NCT03188575: D-IAPT
Effectiveness & Cost-effectiveness of Internet-delivered Interventions for Depression and Anxiety Disorders in IAPT
NA trial testing SilverCloud Internet-delivered Cognitive Behavioural Therapy in Depression in 384 participants. Status unknown.
25 July 2019
Quick facts
| Lead sponsor | Silver Cloud Health |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 384 |
| Start date | 15 June 2017 |
| Primary completion | 25 July 2019 |
| Estimated completion | 30 August 2019 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- SilverCloud Internet-delivered Cognitive Behavioural Therapy
- Waiting List
Conditions studied
- Depression — all drugs for Depression →
- Anxiety Disorders — all drugs for Anxiety Disorders →
- Depressive Disorder — all drugs for Depressive Disorder →
- Generalized Anxiety Disorder — all drugs for Generalized Anxiety Disorder →
Sponsor
Silver Cloud Health
Who can join
Adults 18 to 80, any sex, with Depression or Anxiety Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Depression and anxiety are common mental health problems. There are effective treatments for depression and anxiety and one of these is talking therapies using cognitive behaviour therapy (CBT). In recent years CBT has been transferred to online delivery methods and these interventions have proven successful for people being treated with symptoms of depression and anxiety. The current study will utilise a randomised controlled trial design, where the majority (n=240) of participants will be allocated to the immediate treatment (internet-delivered CBT for either depression or anxiety), and a smaller number (n=120) will be allocated to a waiting list. The waiting list group will receive treatment after an eight week wait. This design helps us to understand that any changes in symptoms in the treatment group will be likely due to the treatment they received compared to the waiting list. A sample size of 360 participants is proposed and has been adjusted to ameliorate against patient dropout. Follow-up and maintenance of any positive changes in symptoms is very important in CBT for depression and anxiety, simply because some people can have a relapse of symptoms. We will therefore follow-up the treatment group for 3, 6, 9 and 12 months to assess maintenance of positive gains from treatment. The study also seeks to investigate the cost effectiveness of the treatments.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety.
Richards D, Enrique A, Eilert N, Franklin M, et al · · 2020 · cited 89× · PMID 32566763 · DOI 10.1038/s41746-020-0293-8 -
Digital IAPT: the effectiveness & cost-effectiveness of internet-delivered interventions for depression and anxiety disorders in the Improving Access to Psychological Therapies programme: study protocol for a randomised control trial.
Richards D, Duffy D, Blackburn B, Earley C, et al · · 2018 · cited 39× · PMID 29499675 · DOI 10.1186/s12888-018-1639-5
Verify or expand the search:
- PubMed search for NCT03188575
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Silver Cloud Health trials
Trials by the same sponsor.
- NCT04568317 — Smartwatch-supported Internet-delivered Intervention for Depression · NA · completed
- NCT04493593 — Internet-delivered CBT-I (Space for Sleep): Pilot and Feasibility · NA · completed
- NCT03271645 — Internet-delivered Interventions for Stress, Anxiety and Depression in the Workplace · NA · withdrawn
- NCT03068676 — Internet-delivered Treatments for Depression and Anxiety in Primary Care (SUMMA) · NA · terminated
- NCT03062215 — Efficacy of a Culturally Adapted Cognitive Behavioural Internet-delivered Treatment for Depression · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03188575 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Silver Cloud Health
- Last refreshed: 10 September 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03188575.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing