NCT03186027 (CONNeCT) is a NA clinical trial of Coenzyme Q10 plus NADH in Chronic Fatigue Syndrome, sponsored by Hospital Universitari Vall d'Hebron Research Institute.

Who is sponsoring NCT03186027?

NCT03186027 is sponsored by Hospital Universitari Vall d'Hebron Research Institute.

What drugs are being tested in NCT03186027?

Interventions in NCT03186027: Coenzyme Q10 plus NADH, phosphoserine plus vitamin C.

What condition does NCT03186027 study?

NCT03186027 studies Chronic Fatigue Syndrome.

Is NCT03186027 still recruiting?

NCT03186027 is currently completed. Last updated 21 September 2022.

Last reviewed 2022-09-21 · How we verify

NCT03186027: CONNeCT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Completed NA Last updated 21 September 2022

What this trial tests

NA trial testing Coenzyme Q10 plus NADH in Chronic Fatigue Syndrome in 282 participants. Completed in 1 September 2021.

Timeline

28 June 2017

Primary endpoint
28 May 2020

1 September 2021

Quick facts

Lead sponsor	Hospital Universitari Vall d'Hebron Research Institute
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	282
Start date	28 June 2017
Primary completion	28 May 2020
Estimated completion	1 September 2021
Sites	1 location across Spain

Drugs / interventions tested

Coenzyme Q10 plus NADH
phosphoserine plus vitamin C

Conditions studied

Chronic Fatigue Syndrome — all drugs for Chronic Fatigue Syndrome →

Sponsor

Hospital Universitari Vall d'Hebron Research Institute

Who can join

Adults 18 to 65, female only, with Chronic Fatigue Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main aim of the study is to examine the effect of oral CoQ10 plus NADH (Reconnect®) supplementation twice daily for 8-weeks on the changes in fatigue perception, sleep disturbances, autonomic dysfunction and HRQoL assessed by patient-reported outcome measures in CFS/ME.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, et al · · 2021 · cited 40× · PMID 34444817 · DOI 10.3390/nu13082658

Verify or expand the search:

Other recruiting trials for Chronic Fatigue Syndrome

Currently open trials in the same condition.

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NCT05741112 — The Long COVID-19 Wearable Device Study · NA · recruiting
NCT05967052 — Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitati · Phase 2 · recruiting
NCT05525598 — Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders · NA · recruiting

Other Hospital Universitari Vall d'Hebron Research Institute trials

Trials by the same sponsor.

NCT07519343 — Migraine and Endometriosis: The FEMININE Study · not yet recruiting
NCT07509541 — Hemodynamic and Respiratory Instability During Percutaneous Pulmonary Thrombectomy · not yet recruiting
NCT07456280 — Evaluation of the Non-invasive Electrocardiographic Monitoring Strategy Associated With Early Discharge in Patients With · NA · not yet recruiting
NCT07281911 — Early Biological and Mechanical Profiling in Sepsis-Associated ARDS · not yet recruiting
NCT07430501 — Using Digital Twin Technology and Clinical Decision Support Systems to Improve the Early Detection, Personalised Treatme · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03186027 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Universitari Vall d'Hebron Research Institute
Last refreshed: 21 September 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03186027.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing