NCT03181334: C-SPAN

The C-SPAN Coalition: Colorectal Cancer Screening and Patient Navigation

Completed NA Last updated 28 April 2021

What this trial tests

NA trial testing Branch I in Colorectal Cancer in 7,711 participants. Completed in 31 December 2020.

Timeline

5 September 2017

Primary endpoint
15 March 2018

31 December 2020

Quick facts

Lead sponsor	University of Texas Southwestern Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	health services research
Enrollment	7,711
Start date	5 September 2017
Primary completion	15 March 2018
Estimated completion	31 December 2020
Sites	2 locations across United States

Drugs / interventions tested

• Branch I
• Branch II
• Branch III
• Branch IV
• Branch V

Conditions studied

• Colorectal Cancer — all drugs for Colorectal Cancer →

Sponsor

University of Texas Southwestern Medical Center

Who can join

Adults 50 to 74, any sex, with Colorectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Participants will be mailed an invitation to complete CRC screening along with a fecal immunochemical test (FIT) kit, containing a 1-sample "Polymedco Over the Counter (OC) Sensor FIT", simplified English/Spanish instructions on performing the test, educational information about colorectal cancer screening and a return mailer with prepaid postage.

Processes that will be used to promote screening completion include automated and "live" phone call reminders to encourage completion of FIT testing.

Participants will be randomly assigned to 1 of 5 interventions across 3 conditions, described below:

1. Condition 1 (Standard Intervention):

* Branch I: Participants assigned to the control condition will receive a FIT kit and the standard invitation letter to participate in free screening.
2. Condition 2 (Time Guideline):

* Branch II: Participants will receive a FIT kit and invitation letter to participate in free screening with a 1-week time restriction.
* Branch III: Participants will receive a FIT kit and invitation letter to participate in free screening with a 3-week time restriction.
3. Condition 3 (Time Guideline + Incentive):

* Branch IV: Participants will receive a FIT kit and invitation letter to participate in free screening requesting they return the kit within 1-week for a "higher" monetary incentive or within 3 weeks for a "lower" (half of the higher) monetary incentive.
* Branch V: Participants will receive a FIT kit and invitation letter to participate in free screening requesting they return the kit within 1-week for a "higher" (same as lower in Branch IV) monetary incentive or within 3 weeks for a "lower" (half of the higher) monetary incentive.

Participants with a normal test result will receive a personal letter confirming this with invitations to complete a repeat screening in subsequent year(s). Participants receiving an abnormal FIT result will be navigated to complete a diagnostic colonoscopy.

Participants continuing in the screening program in subsequent years will receive letters emphasizing the importance of repeat screening to prevent adverse CRC outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The effect of deadlines on cancer screening completion: a randomized controlled trial.
   Lieberman A, Gneezy A, Berry E, Miller S, et al · · 2021 · cited 13× · PMID 34230556 · DOI 10.1038/s41598-021-93334-1