NCT03180879 is a Phase 1 clinical trial of Test - RB ibuprofen acid orodispersible tablets in Healthy, sponsored by Reckitt Benckiser Healthcare (UK) Limited.

Who is sponsoring NCT03180879?

NCT03180879 is sponsored by Reckitt Benckiser Healthcare (UK) Limited.

What drugs are being tested in NCT03180879?

Interventions in NCT03180879: Test - RB ibuprofen acid orodispersible tablets, Reference - RB Nurofen ibuprofen acid tablets, Comparator - Dolormin ibuprofen lysine tablets.

Is NCT03180879 still recruiting?

NCT03180879 is currently completed. Last updated 5 October 2017.

Last reviewed 2017-10-05 · How we verify

NCT03180879

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ibuprofen Bioavailability Study

Completed Phase 1 Last updated 5 October 2017

What this trial tests

Phase 1 trial testing Test - RB ibuprofen acid orodispersible tablets in Healthy in 36 participants. Completed in 13 June 2017.

Timeline

10 April 2017

Primary endpoint
13 June 2017

13 June 2017

Quick facts

Lead sponsor	Reckitt Benckiser Healthcare (UK) Limited
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	36
Start date	10 April 2017
Primary completion	13 June 2017
Estimated completion	13 June 2017
Sites	1 location across United Kingdom

Drugs / interventions tested

Test - RB ibuprofen acid orodispersible tablets — full drug profile →
Reference - RB Nurofen ibuprofen acid tablets — full drug profile →
Comparator - Dolormin ibuprofen lysine tablets — full drug profile →

Conditions studied

Healthy — all drugs for Healthy →

Sponsor

Reckitt Benckiser Healthcare (UK) Limited — full company profile →

Who can join

Adults 18 to 50, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project is the in-house development of a 200 mg ibuprofen acid orodispersable tablet (ODT; meltlet). It is designed to appeal to consumers who want a dosage form that may be taken without water and can be used 'on the go'. Vanquish has an improved organoleptic profile compared to the currently marketed meltet by the Sponsor. ODTs are also considered as a suitable dosage form for children who may be reluctant to swallow tablets. This product has the potential for application in both adults and children due to the convenience of the format and the ease of administration for both groups. This will be the first pharmacokinetic (PK) assessment of the ibuprofen acid ODT formulation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparative Bioavailability Study of a New Orodispersible Formulation of Ibuprofen Versus Two Existing Oral Tablet Formulations in Healthy Male and Female Volunteers.
Sugár D, Francombe D, da Silva T, Hanid S, et al · · 2019 · cited 4× · PMID 31202508 · DOI 10.1016/j.clinthera.2019.04.040

Verify or expand the search:

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Other Reckitt Benckiser Healthcare (UK) Limited trials

Trials by the same sponsor.

NCT06777797 — Prospective, Verification Study to Assess Condom Fit Across Polyurethane (PU) and Natural Rubber Latex (NRL) Condoms · NA · completed
NCT06557499 — A 3-way Crossover Clinical Investigation to Assess the Performance of Two Different Sized Polyurethane Condoms Versus a · NA · recruiting
NCT05840172 — A Clinical Investigation to Assess the Effectiveness of Benzocaine in NRL Condoms in Healthy Adult Men Who Feel They Eja · NA · completed
NCT05644444 — Effectiveness and Safety of a Water-based and a Silicone-based Personal Lubricants With Sensory Action · NA · completed
NCT05689814 — Retention, Stability and Performance Assessment of Denture Fixatives Versus no Fixative Control · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03180879 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Reckitt Benckiser Healthcare (UK) Limited
Last refreshed: 5 October 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03180879.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing