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NCT03176719: NOVAC

Non-specific Effects of Vaccination on Mortality and Morbidity

Status unknown Last updated 4 September 2018
What this trial tests

trial testing Venipuncture in Vaccine Reaction in 1,005 participants. Status unknown.

Timeline
17 June 2017
Primary endpoint
31 October 2017
31 December 2018

Quick facts

Lead sponsorRadboud University Medical Center
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment1,005
Start date17 June 2017
Primary completion31 October 2017
Estimated completion31 December 2018
Sites1 location across Burkina Faso

Drugs / interventions tested

Conditions studied

Sponsor

Radboud University Medical Center

Who can join

1 and older, any sex, with Vaccine Reaction or Anemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

It has long been recognized that the positive effects of vaccination on childhood mortality cannot be solely attributed to a decline in the disease targeted by the vaccine. These so-called non-specific effects of vaccination have so far mostly been linked to mortality. However, it has been suggested that non-specific effects may also effect morbidity and nutritional status. This study aims to further explore the correlation between vaccination, susceptibility to infectious diseases (particularly malaria and bacterial infections), nutritional status and immunity. With this prospective cross sectional study among healthy individuals in rural west-Africa we aim to address several research questions at the same time. This study will assess the influence of (time-point of) vaccination on morbidity, mortality and immune status among healthy individuals in a rural sub-Saharan African setting. Secondly, to explore the prevalence of subclinical malaria, iron deficiency anemia, sickle cell anemia and thallasemia among a healthy rural sub-Saharan African population. And finally to assess normal hemocytometry values among a healthy rural sub-Saharan African population.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Red blood cell homeostasis in children and adults with and without asymptomatic malaria infection in Burkina Faso.
    Kaboré B, Post A, Berendsen MLT, Diallo S, et al · · 2020 · cited 8× · PMID 33253198 · DOI 10.1371/journal.pone.0242507
  2. Altered <i>Ex-Vivo</i> Cytokine Responses in Children With Asymptomatic <i>Plasmodium falciparum</i> Infection in Burkina Faso: An Additional Argument to Treat Asymptomatic Malaria?
    Post A, Kaboré B, Berendsen M, Diallo S, et al · · 2021 · cited 6× · PMID 34177883 · DOI 10.3389/fimmu.2021.614817
  3. Infection Manager System (IMS) as a new hemocytometry-based bacteremia detection tool: A diagnostic accuracy study in a malaria-endemic area of Burkina Faso.
    Post A, Kaboré B, Bognini J, Diallo S, et al · · 2021 · cited 5× · PMID 33647009 · DOI 10.1371/journal.pntd.0009187
  4. Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study.
    Neyer PJ, Kaboré B, Nakas CT, Hartmann B, et al · · 2023 · cited 1× · PMID 37658365 · DOI 10.1186/s12936-023-04686-0

Verify or expand the search:

Other trials of Venipuncture

Trials testing the same drug.

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Other Radboud University Medical Center trials

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Data sources for this page

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing