Neural Mechanisms Underlying the Antidepressant Effects of Sleep Deprivation

NCT03169543 NA COMPLETED

From 40 to 60% of patients with depression experience a rapid and significant improvement of mood with one night of sleep deprivation (SD). The neural mechanisms underlying this effect have not been elucidated. Recent advances in functional neuroimaging have provided new opportunities to investigate state changes in regional brain function, along with a better understanding of the neural networks affected by depression and SD. Here we propose to study a group of N=48 antidepressant-free male and female patients with current depression symptom and N=12 healthy controls with no history of mood disorders before and after SD to provide mechanistic insight into the neural substrates underlying the antidepressant effects of SD. We hypothesize that SD-induced concurrent functional activity and connectivity changes in multiple brain networks related to different depressive symptom dimensions including emotion regulation, attention, arousal, self-referential, and reward processing will underlie the rapid and transient antidepressant effects of SD. Using an ABA design, multimodal brain imaging along with more traditional electroencephalographic (EEG) and neurobehavioral testing data will be acquired at baseline after normal sleep, during one night of total SD, and after one night of recovery sleep using a 5-day in laboratory protocol during which subjects will be continuously monitored by trained staff.

Details

Lead sponsor	University of Pennsylvania
Phase	NA
Status	COMPLETED
Enrolment	50
Start date	Fri Apr 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Fri Feb 28 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Depression, Unipolar

Interventions

• Sleep deprivation

Countries

United States