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Paediatric Obesity and Cardiovascular Dysfunction
Background Childhood obesity has been related to an impaired cardiovascular structure and function. Aims of this study will be to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, to investigate the potential association with insulin resistance (IR), serum uric acid (sUA), metabolic syndrome (MetS), plasmatic markers of inflammation and oxidative stress and adipokines, to evaluate changes in cardiovascular dysfunction after 6 and 12 months of a behavioral treatment (isocaloric Mediterranean balanced diet plus daily aerobic physical activity). Subjects and methods This was a single-center case-control study. Eighty obese (OB) subjects (6-16 years) and 20 normal weight (NW) matched controls were consecutively recruited. In the whole population we will perform an anthropometric and a cardiovascular assessment. OB patients will also undergo an OGTT and biochemical evaluations. In the OB group, all these evaluations will be performed at baseline and after 6 (T6) and 12 months (T12) of diet plus aerobic training.
Details
| Lead sponsor | Azienda Ospedaliero Universitaria Maggiore della Carita |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 100 |
| Start date | Thu Jan 15 2015 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Jul 21 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Obesity, Childhood
- Cardiovascular Diseases
Interventions
- diet plus physical activity